Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.
Adult
Aged
Aged, 80 and over
Alzheimer Disease
/ diagnostic imaging
Amyloid beta-Peptides
/ metabolism
Brain Cortical Thickness
CA1 Region, Hippocampal
/ diagnostic imaging
Case-Control Studies
DNA-Binding Proteins
/ metabolism
Entorhinal Cortex
/ diagnostic imaging
Female
Frontotemporal Lobar Degeneration
/ diagnostic imaging
Hippocampus
/ diagnostic imaging
Humans
Lewy Body Disease
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Neurodegenerative Diseases
/ diagnostic imaging
Neurofibrillary Tangles
/ pathology
Parahippocampal Gyrus
/ diagnostic imaging
Pick Disease of the Brain
/ diagnostic imaging
Plaque, Amyloid
/ pathology
Supranuclear Palsy, Progressive
/ diagnostic imaging
Temporal Lobe
/ diagnostic imaging
alpha-Synuclein
/ metabolism
tau Proteins
/ metabolism
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
21 07 2021
21 07 2021
Historique:
received:
18
06
2021
accepted:
06
07
2021
entrez:
22
7
2021
pubmed:
23
7
2021
medline:
27
1
2022
Statut:
epublish
Résumé
The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated associations between neurodegenerative pathologies and the thickness of different MTL subregions measured using high-resolution post-mortem MRI. Tau, TAR DNA-binding protein 43 (TDP-43), amyloid-β and α-synuclein pathology were rated on a scale of 0 (absent)-3 (severe) in the hippocampus and entorhinal cortex (ERC) of 58 individuals with and without neurodegenerative diseases (median age 75.0 years, 60.3% male). Thickness measurements in ERC, Brodmann Area (BA) 35 and 36, parahippocampal cortex, subiculum, cornu ammonis (CA)1 and the stratum radiatum lacunosum moleculare (SRLM) were derived from 0.2 × 0.2 × 0.2 mm
Identifiants
pubmed: 34289895
doi: 10.1186/s40478-021-01225-3
pii: 10.1186/s40478-021-01225-3
pmc: PMC8293481
doi:
Substances chimiques
Amyloid beta-Peptides
0
DNA-Binding Proteins
0
MAPT protein, human
0
SNCA protein, human
0
TARDBP protein, human
0
alpha-Synuclein
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
128Subventions
Organisme : NIA NIH HHS
ID : P30 AG010124
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072979
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055005
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056014
Pays : United States
Informations de copyright
© 2021. The Author(s).
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