Mechanistic Investigation of Castagnoli-Cushman Multicomponent Reactions Leading to a Three-Component Synthesis of Dihydroisoquinolones.
Journal
The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R
Informations de publication
Date de publication:
03 09 2021
03 09 2021
Historique:
pubmed:
6
8
2021
medline:
25
2
2023
entrez:
5
8
2021
Statut:
ppublish
Résumé
The mechanisms for the three- and four-component variants of the Castagnoli-Cushman reaction (CCR) have been investigated. A series of crossover experiments were conducted to probe the structure and reactivity of known amide-acid intermediates for the three- and four-component variants of the CCR (3CR and 4CR, respectively). Control experiments paired with
Identifiants
pubmed: 34351161
doi: 10.1021/acs.joc.1c01163
doi:
Substances chimiques
Aldehydes
0
Amides
0
Amines
0
Anhydrides
0
Imines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM