miRNA-132/212 Gene-Deletion Aggravates the Effect of Oxygen-Glucose Deprivation on Synaptic Functions in the Female Mouse Hippocampus.
Acetylcholine
/ metabolism
Acetylcholinesterase
/ genetics
Animals
Base Sequence
Brain Ischemia
/ genetics
Cholinergic Neurons
/ drug effects
Dentate Gyrus
/ metabolism
Excitatory Postsynaptic Potentials
/ physiology
Female
GPI-Linked Proteins
/ genetics
Gene Expression Regulation
Glucose
/ deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
MicroRNAs
/ genetics
Microtomy
Oxygen
/ pharmacology
Patch-Clamp Techniques
Receptor, Muscarinic M1
/ genetics
Sequence Deletion
Synaptic Transmission
Tissue Culture Techniques
acetylcholine
dentate gyrus
field excitatory postsynaptic potentials (fEPSP)
hippocampus
hypoxia
ischemia
miRNA 132/212
oxygen-glucose deprivation (OGD)
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 07 2021
06 07 2021
Historique:
received:
10
06
2021
revised:
01
07
2021
accepted:
02
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
29
10
2021
Statut:
epublish
Résumé
Cerebral ischemia and its sequelae, which include memory impairment, constitute a leading cause of disability worldwide. Micro-RNAs (miRNA) are evolutionarily conserved short-length/noncoding RNA molecules recently implicated in adaptive/maladaptive neuronal responses to ischemia. Previous research independently implicated the miRNA-132/212 cluster in cholinergic signaling and synaptic transmission, and in adaptive/protective mechanisms of neuronal responses to hypoxia. However, the putative role of miRNA-132/212 in the response of synaptic transmission to ischemia remained unexplored. Using hippocampal slices from female miRNA-132/212 double-knockout mice in an established electrophysiological model of ischemia, we here describe that miRNA-132/212 gene-deletion aggravated the deleterious effect of repeated oxygen-glucose deprivation insults on synaptic transmission in the dentate gyrus, a brain region crucial for learning and memory functions. We also examined the effect of miRNA-132/212 gene-deletion on the expression of key mediators in cholinergic signaling that are implicated in both adaptive responses to ischemia and hippocampal neural signaling. miRNA-132/212 gene-deletion significantly altered hippocampal AChE and mAChR-M1, but not α7-nAChR or MeCP2 expression. The effects of miRNA-132/212 gene-deletion on hippocampal synaptic transmission and levels of cholinergic-signaling elements suggest the existence of a miRNA-132/212-dependent adaptive mechanism safeguarding the functional integrity of synaptic functions in the acute phase of cerebral ischemia.
Identifiants
pubmed: 34359879
pii: cells10071709
doi: 10.3390/cells10071709
pmc: PMC8306255
pii:
doi:
Substances chimiques
GPI-Linked Proteins
0
MIRN132 microRNA, mouse
0
MIRN212 microRNA, mouse
0
MicroRNAs
0
Receptor, Muscarinic M1
0
Acetylcholinesterase
EC 3.1.1.7
Ache protein, mouse
EC 3.1.1.7
Glucose
IY9XDZ35W2
Acetylcholine
N9YNS0M02X
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund FWF
ID : P 31004
Pays : Austria
Références
Neuroscience. 2017 Sep 17;359:308-324
pubmed: 28720379
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4351-6
pubmed: 10759548
Brain Res. 1985 Jul 1;337(2):337-40
pubmed: 2992681
Exp Lung Res. 2015 Jun;41(5):261-9
pubmed: 26052826
Transl Stroke Res. 2019 Dec;10(6):672-683
pubmed: 30617994
Ann Med. 2016 Dec;48(8):652-668
pubmed: 27558977
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6644-9
pubmed: 21464314
Hippocampus. 1991 Oct;1(4):399-404
pubmed: 1669318
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16426-31
pubmed: 16260724
Neurochem Int. 2019 Jul;127:56-63
pubmed: 30391509
Br J Pharmacol. 2009 Jul;157(5):818-30
pubmed: 19422385
Nat Med. 2012 Jul;18(7):1087-94
pubmed: 22683779
Pharmacol Biochem Behav. 2003 Mar;74(4):977-86
pubmed: 12667913
Neurosci Lett. 2000 May 12;285(2):91-4
pubmed: 10793234
J Exp Med. 2007 Jul 9;204(7):1553-8
pubmed: 17606634
J Alzheimers Dis. 2014;40(4):1029-38
pubmed: 24577459
Mol Neurobiol. 2019 Dec;56(12):8376-8391
pubmed: 31240600
Brain Struct Funct. 2013 Jan;218(1):59-72
pubmed: 22246100
Exp Neurol. 2011 Dec;232(2):329-32
pubmed: 21945008
Neuropsychiatr Dis Treat. 2018 Dec 24;15:95-103
pubmed: 30636875
Front Neurosci. 2015 Apr 21;9:118
pubmed: 25954143
Exp Ther Med. 2012 Apr;3(4):571-576
pubmed: 22969931
Microrna. 2018;7(1):4-10
pubmed: 29372676
Nat Rev Dis Primers. 2019 Oct 10;5(1):70
pubmed: 31601801
Neuroscience. 1991;40(3):599-636
pubmed: 1676492
EBioMedicine. 2019 Jan;39:409-421
pubmed: 30522932
Int J Mol Sci. 2017 Jan 17;18(1):
pubmed: 28106731
Neurobiol Dis. 2014 Feb;62:8-17
pubmed: 24055213
Immunity. 2009 Dec 18;31(6):965-73
pubmed: 20005135
Prog Brain Res. 2016;226:155-78
pubmed: 27323942
J Neurophysiol. 1997 Aug;78(2):891-902
pubmed: 9307122
Cell. 2001 Dec 28;107(7):823-6
pubmed: 11779458
Eur J Immunol. 2013 Oct;43(10):2771-82
pubmed: 23780851
NeuroRehabilitation. 2010;26(1):47-63
pubmed: 20130355
Int J Clin Exp Med. 2014 Jul 15;7(7):1639-49
pubmed: 25126160
Eur J Neurosci. 2020 Sep;52(6):3610-3627
pubmed: 32022336
Ann Biomed Eng. 1997 Sep-Oct;25(5):870-3
pubmed: 9300111
Nat Genet. 2002 Apr;30(4):363-4
pubmed: 11896390
Front Pharmacol. 2018 Apr 24;9:399
pubmed: 29740323
Nat Neurosci. 2009 Apr;12(4):399-408
pubmed: 19287386
Prog Brain Res. 1985;63:39-58
pubmed: 3835581
Br J Pharmacol. 1999 Nov;128(5):1035-44
pubmed: 10556941
Addict Biol. 2021 Mar;26(2):e12905
pubmed: 32293776
Annu Rev Psychol. 2010;61:111-40, C1-3
pubmed: 19575621
J Cent Nerv Syst Dis. 2016 Jun 20;8:5-11
pubmed: 27375363
Neural Regen Res. 2015 Oct;10(10):1537-9
pubmed: 26692832
Eur J Neurosci. 2009 Jan;29(2):319-27
pubmed: 19200237
Epilepsia. 2013 Jul;54(7):1223-31
pubmed: 23815572
Neuron. 2017 Sep 27;96(1):17-42
pubmed: 28957666
Learn Mem. 2016 Jan 15;23(2):61-71
pubmed: 26773099
Sci Rep. 2017 Feb 17;7:42755
pubmed: 28209997
Stroke Res Treat. 2013;2013:276540
pubmed: 23533957
Brain Res. 2001 Jul 13;907(1-2):144-50
pubmed: 11430897
Eur J Pharmacol. 1992 Oct 6;221(1):113-9
pubmed: 1459186
Brain Res Bull. 2019 Sep;151:174-180
pubmed: 31132418
Neuropharmacology. 2013 Apr;67:511-20
pubmed: 23261865
Methods Mol Biol. 2015;1254:197-210
pubmed: 25431067
J Cereb Blood Flow Metab. 2010 Apr;30(4):744-56
pubmed: 20010955
Curr Med Chem. 2015;22(10):1292-301
pubmed: 25666793
Sci Rep. 2018 Feb 27;8(1):3703
pubmed: 29487336
FASEB J. 2017 Feb;31(2):424-433
pubmed: 28148775
Behav Brain Res. 2019 Nov 5;373:112109
pubmed: 31340175
RNA Dis. 2016;3(2):
pubmed: 27713923
Neuropharmacology. 2002 Mar;42(4):459-66
pubmed: 11955517
Eur J Pharmacol. 2011 Dec 15;672(1-3):96-105
pubmed: 21924263
Neuroscience. 2004;128(3):635-44
pubmed: 15381291
Br J Anaesth. 2005 Apr;94(4):486-91
pubmed: 15708869
Behav Brain Res. 2009 Oct 12;203(1):1-14
pubmed: 19446892
PLoS One. 2013 Apr 26;8(4):e62509
pubmed: 23658634
Neurosci Lett. 1986 Jun 6;67(1):92-6
pubmed: 3014393
Brain Res. 1995 Apr 17;677(1):127-37
pubmed: 7606456
Nat Rev Neurosci. 2001 Apr;2(4):294-302
pubmed: 11283752
PLoS One. 2009;4(3):e4846
pubmed: 19287501
Acta Neuropathol. 2018 Oct;136(4):537-555
pubmed: 29982852
Int J Stroke. 2012 Jul;7(5):378-85
pubmed: 22712739
Mol Neurobiol. 2020 Mar;57(3):1432-1445
pubmed: 31754996
Neurosci Lett. 1996 Jan 26;203(3):195-8
pubmed: 8742026
Neurosci Lett. 2016 Sep 19;631:91-96
pubmed: 27546825
Neuron. 2015 Jul 15;87(2):297-309
pubmed: 26182415
Front Mol Neurosci. 2018 Dec 20;11:471
pubmed: 30618618
Brain Res. 2015 Oct 5;1622:484-95
pubmed: 26168887
J Mol Neurosci. 2016 Jul;59(3):404-10
pubmed: 27074745
Nucleic Acids Res. 2012 Jun;40(11):4742-53
pubmed: 22362752
J Biol Chem. 2004 Oct 1;279(40):41521-8
pubmed: 15280370
Biochem Biophys Res Commun. 2015 May 15;460(4):931-7
pubmed: 25839659
J Cell Biochem. 2020 Jan;121(1):135-141
pubmed: 31578769
Lancet Neurol. 2019 May;18(5):439-458
pubmed: 30871944
Epilepsia. 2002;43 Suppl 5:188-93
pubmed: 12121319
J Neurophysiol. 2009 Feb;101(2):1016-32
pubmed: 19073793
Eur J Neurol. 2015 Sep;22(9):1288-94
pubmed: 26040251
Science. 2005 May 6;308(5723):833-8
pubmed: 15774722
Epilepsia. 2005;46 Suppl 5:142-7
pubmed: 15987269
Aging Cell. 2020 Jan;19(1):e13046
pubmed: 31625272
Cells. 2019 Dec 17;8(12):
pubmed: 31861141
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
ScientificWorldJournal. 2013 Dec 02;2013:459692
pubmed: 24363618
Brain Res. 2014 Jan 16;1543:271-9
pubmed: 24211659
Int J Immunopathol Pharmacol. 2017 Sep;30(3):253-263
pubmed: 28627974
Neurosci Biobehav Rev. 2011 Jan;35(3):565-72
pubmed: 20620164
Reprod Sci. 2011 Feb;18(2):172-9
pubmed: 20959640
Crit Rev Neurobiol. 1991;6(3):149-82
pubmed: 1773451
Br J Pharmacol. 2003 Sep;140(2):305-14
pubmed: 12970092
Neural Plast. 2016;2016:5108489
pubmed: 27579184
PLoS One. 2017 Apr 27;12(4):e0176547
pubmed: 28448626
J Neurochem. 2006 Jan;96(2):510-9
pubmed: 16336219
Stroke. 2019 Dec;50(12):e344-e418
pubmed: 31662037
Food Funct. 2018 Mar 1;9(3):1532-1544
pubmed: 29431797
Neural Plast. 2016;2016:4959523
pubmed: 27034846
Ann Transl Med. 2014 Aug;2(8):80
pubmed: 25333055
Nat Rev Neurol. 2017 Sep;13(9):521-532
pubmed: 28731036