Amplification by tramadol of PGD

Analgesics, Opioid / pharmacology Animals Anthracenes / pharmacology Bone Remodeling / drug effects Enzyme Inhibitors / pharmacology Fluvoxamine / pharmacology Imidazoles / pharmacology JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors Mice Naloxone / pharmacology Narcotic Antagonists / pharmacology Osteoblasts / drug effects Osteoprotegerin / biosynthesis Prostaglandin D2 / pharmacology Pyridines / pharmacology RNA, Messenger / drug effects Receptors, Opioid, mu / agonists Serotonin Plasma Membrane Transport Proteins / metabolism Selective Serotonin Reuptake Inhibitors / pharmacology Sertraline / pharmacology Tramadol / pharmacology p38 Mitogen-Activated Protein Kinases / drug effects
5-Hydroxytryptamine transporter Osteoblast Osteoprotegerin Prostaglandin D(2) Tramadol μ-Opioid receptor

Journal

Prostaglandins, leukotrienes, and essential fatty acids
ISSN: 1532-2823
Titre abrégé: Prostaglandins Leukot Essent Fatty Acids
Pays: Scotland
ID NLM: 8802730

Informations de publication

Date de publication:
09 2021
Historique:
received: 22 05 2021
revised: 21 07 2021
accepted: 03 08 2021
pubmed: 16 8 2021
medline: 15 2 2022
entrez: 15 8 2021
Statut: ppublish

Résumé

Tramadol, a weak μ-opioid receptor (MOR) agonist with inhibitory effects on the reuptake of serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine, is an effective analgesic to chronic pains. Osteoprotegerin produced by osteoblasts is essential for bone remodeling to suppress osteoclastic bone resorption. We previously reported that prostaglandin D

Identifiants

DOI: 10.1016/j.plefa.2021.102323 PMID: 34392133
pubmed: 34392133
pii: S0952-3278(21)00085-5
doi: 10.1016/j.plefa.2021.102323
pii:
doi:

Substances chimiques

Analgesics, Opioid 0
Anthracenes 0
Enzyme Inhibitors 0
Imidazoles 0
Narcotic Antagonists 0
Osteoprotegerin 0
Pyridines 0
RNA, Messenger 0
Receptors, Opioid, mu 0
Serotonin Plasma Membrane Transport Proteins 0
Serotonin Uptake Inhibitors 0
pyrazolanthrone 1TW30Y2766
Naloxone 36B82AMQ7N
Tramadol 39J1LGJ30J
JNK Mitogen-Activated Protein Kinases EC 2.7.11.24
p38 Mitogen-Activated Protein Kinases EC 2.7.11.24
Fluvoxamine O4L1XPO44W
SB 203580 OU13V1EYWQ
Sertraline QUC7NX6WMB
Prostaglandin D2 RXY07S6CZ2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102323

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Tomoyuki Hioki (T)

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan; Department of Dermatology, Kizawa Memorial Hospital, Minokamo, Gifu 505-8503, Japan; Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.

Haruhiko Tokuda (H)

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan; Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan; Department of Clinical Laboratory/Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.

Kumiko Tanabe (K)

Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Woo Kim (W)

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Junko Tachi (J)

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan; Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Shinobu Yamaguchi (S)

Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Rie Matsushima-Nishiwaki (R)

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Osamu Kozawa (O)

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan; Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan. Electronic address: okkasugai@yahoo.co.jp.

Hiroki Iida (H)

Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Amplification by tramadol of PGD
questionsmedicales.fr › Eucaryotes › Animaux › Amplification by tramadol of PGD
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Anthracènes › Amplification by tramadol of PGD
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Amplification by tramadol of PGD
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Amplification by tramadol of PGD
questionsmedicales.fr › Composés chimiques organiques › Amines › Hydroxylamines › Oximes › Fluvoxamine › Amplification by tramadol of PGD
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Amplification by tramadol of PGD
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › JNK Mitogen-Activated Protein Kinases › Amplification by tramadol of PGD
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Amplification by tramadol of PGD
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Naloxone › Amplification by tramadol of PGD
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Antagonistes narcotiques › Amplification by tramadol of PGD
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Amplification by tramadol of PGD
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteurs leurres aux facteurs de nécrose tumorale › Ostéoprotégérine › Amplification by tramadol of PGD
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines D › Prostaglandine D2 › Amplification by tramadol of PGD
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Amplification by tramadol of PGD
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Amplification by tramadol of PGD
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › Amplification by tramadol of PGD
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la sérotonine › Amplification by tramadol of PGD
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents sérotoninergiques › Inhibiteurs sélectifs de la recapture de la sérotonine › Amplification by tramadol of PGD
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › 1-Naphtylamine › Sertraline › Amplification by tramadol of PGD
questionsmedicales.fr › Lipides › Alcools gras › Hexanols › Cyclohexanols › Tramadol › Amplification by tramadol of PGD
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › p38 Mitogen-Activated Protein Kinases › Amplification by tramadol of PGD