Inducible Population Quality Control of Engineered

Bacillus subtilis / chemistry Bacterial Proteins / genetics Metabolic Engineering / methods N-Acetylneuraminic Acid / biosynthesis Plasmids / genetics Promoter Regions, Genetic Quality Control
Bacillus subtilis N-acetylneuraminic acid biosensor cell growth and product synthesis coupling genetic circuit inducible population quality control

Journal

ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075

Informations de publication

Date de publication:
17 09 2021
Historique:
pubmed: 19 8 2021
medline: 27 1 2022
entrez: 18 8 2021
Statut: ppublish

Résumé

Biosynthesis by microorganisms using renewable feedstocks is an important approach for realizing sustainable chemical manufacturing. However, cell-to-cell variation in biosynthesis capability during fermentation restricts the robustness and efficiency of bioproduction, hampering the industrialization of biosynthesis. Herein, we developed an inducible population quality control system (iPopQC) for dynamically modulating the producing and nonproducing subpopulations of engineered

Identifiants

DOI: 10.1021/acssynbio.1c00086 PMID: 34404207
pubmed: 34404207
doi: 10.1021/acssynbio.1c00086
doi:

Substances chimiques

Bacterial Proteins 0
N-Acetylneuraminic Acid GZP2782OP0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2197-2209

Auteurs

Yanting Cao (Y)

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.

Rongzhen Tian (R)

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.

Xueqin Lv (X)

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.

Jianghua Li (J)

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.

Long Liu (L)

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.

Guocheng Du (G)

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.

Jian Chen (J)

Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, 214122, China.

Yanfeng Liu (Y)

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China.
ORCID: 0000-0002-0562-9647

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Bacillus › Bacillus subtilis › Inducible Population Quality Control of Engineered
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Inducible Population Quality Control of Engineered
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Inducible Population Quality Control of Engineered
questionsmedicales.fr › Glucides › Oses acides › Acides neuraminiques › Acides sialiques › Acide N-acétyl-neuraminique › Inducible Population Quality Control of Engineered
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Plasmides › Inducible Population Quality Control of Engineered
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Inducible Population Quality Control of Engineered
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Contrôle de qualité › Inducible Population Quality Control of Engineered