Development and Validation of StrataNGS, a Multiplex PCR, Semiconductor Sequencing-Based Comprehensive Genomic Profiling Test.
Biomarkers, Tumor
/ genetics
DNA Copy Number Variations
Data Accuracy
Exome
Feasibility Studies
Gene Fusion
Genome, Human
Genomics
/ methods
High-Throughput Nucleotide Sequencing
/ methods
Humans
Limit of Detection
Microsatellite Instability
Multiplex Polymerase Chain Reaction
/ methods
Neoplasms
/ genetics
Reproducibility of Results
Sequence Analysis, DNA
/ methods
Sequence Analysis, RNA
/ methods
Journal
The Journal of molecular diagnostics : JMD
ISSN: 1943-7811
Titre abrégé: J Mol Diagn
Pays: United States
ID NLM: 100893612
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
25
11
2020
revised:
09
07
2021
accepted:
03
08
2021
pubmed:
29
8
2021
medline:
4
3
2022
entrez:
28
8
2021
Statut:
ppublish
Résumé
Despite widespread use in targeted tumor testing, multiplex PCR/semiconductor (Ion Torrent) sequencing-based assessment of all comprehensive genomic profiling (CGP) variant classes has been limited. Herein, we describe the development and validation of StrataNGS, a 429-gene, multiplex PCR/semiconductor sequencing-based CGP laboratory-developed test performed on co-isolated DNA and RNA from formalin-fixed, paraffin-embedded tumor specimens with ≥2 mm
Identifiants
pubmed: 34454112
pii: S1525-1578(21)00257-9
doi: 10.1016/j.jmoldx.2021.08.005
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1515-1533Informations de copyright
Copyright © 2021 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.