Synthesis, α-amylase and α-glucosidase inhibition and molecular docking studies of indazole derivatives.

alpha-Glucosidases / chemistry alpha-Amylases / metabolism Molecular Docking Simulation Glycoside Hydrolase Inhibitors / pharmacology Indazoles / pharmacology Structure-Activity Relationship Molecular Structure
FTIR HR-MS Indazole NMR molecular docking spectral studies α-amylase activity α-glucosidase activity

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
2022
Historique:
pubmed: 1 9 2021
medline: 21 12 2022
entrez: 31 8 2021
Statut: ppublish

Résumé

Herein, we report the synthesis and inhibitory potential of indazole (Methyl 1

Identifiants

DOI: 10.1080/07391102.2021.1947892 PMID: 34463216
pubmed: 34463216
doi: 10.1080/07391102.2021.1947892
doi:

Substances chimiques

alpha-Glucosidases EC 3.2.1.20
alpha-Amylases EC 3.2.1.1
Glycoside Hydrolase Inhibitors 0
Indazoles 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10730-10740

Auteurs

Muhammad Nawaz (M)

Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
ORCID: 0000-0001-9016-9229

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Faiza Qureshi (F)

Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Deanship of Scientific Research, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Nisar Ullah (N)

Chemistry Department, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia.

Manikandan Selvaraj (M)

School of Chemical Engineering, Monash University, Selangor Darul Ehsan, Malaysia.

Sumaira Shahzad (S)

School of Business Administration, College of International Education, Zhejiang Gongshang University, Hangzhou, China.

Sridevi Chigurupati (S)

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia.

Samar A Abubshait (SA)

Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Chemistry, College of Science and Basic & Applied Scientific Research Centre, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Tauqir Ahmad (T)

Chemistry Department, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia.

Sampath Chinnam (S)

Department of Chemistry, B.M.S. College of Engineering, Bengaluru, Karnataka, India.
ORCID: 0000-0002-5334-9076

Soleiman Hisaindee (S)

Chemistry Department, College of Science, United Arab Emirates University, Al-Ain, UAE.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Synthesis, α-amylase and α-glucosidase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › alpha-Amylases › Synthesis, α-amylase and α-glucosidase...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis, α-amylase and α-glucosidase...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Synthesis, α-amylase and α-glucosidase...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indazoles › Synthesis, α-amylase and α-glucosidase...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis, α-amylase and α-glucosidase...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis, α-amylase and α-glucosidase...