Grass Carp Reovirus VP56 Allies VP4, Recruits, Blocks, and Degrades RIG-I to More Effectively Attenuate IFN Responses and Facilitate Viral Evasion.
Animals
Capsid Proteins
/ genetics
Carps
/ virology
Cell Line
DEAD Box Protein 58
/ metabolism
Fish Diseases
/ virology
Fisheries
/ economics
Interferons
/ immunology
RNA Interference
RNA, Small Interfering
/ genetics
RNA, Viral
/ genetics
RNA-Seq
Reoviridae
/ immunology
Reoviridae Infections
/ veterinary
Tandem Mass Spectrometry
Ubiquitination
RIG-I
fibrin VP56
grass carp reovirus
host-virus protein interaction
interferon
major outer capsid protein VP4
viral evasion
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
31 10 2021
31 10 2021
Historique:
pubmed:
16
9
2021
medline:
2
2
2022
entrez:
15
9
2021
Statut:
ppublish
Résumé
Grass carp reovirus (GCRV), the most virulent aquareovirus, causes epidemic hemorrhagic disease and tremendous economic loss in freshwater aquaculture industry. VP56, a putative fibrin inlaying the outer surface of GCRV-II and GCRV-III, is involved in cell attachment. In the present study, we found that VP56 localizes at the early endosome, lysosome, and endoplasmic reticulum, recruits the cytoplasmic viral RNA sensor retinoic acid-inducible gene I (RIG-I) and binds to it. The interaction between VP56 and RIG-I was detected by endogenous coimmunoprecipitation (co-IP), glutathione
Identifiants
pubmed: 34523975
doi: 10.1128/Spectrum.01000-21
pmc: PMC8557896
doi:
Substances chimiques
Capsid Proteins
0
RNA, Small Interfering
0
RNA, Viral
0
Interferons
9008-11-1
DEAD Box Protein 58
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0100021Références
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