Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome.
Adult
Autoantibodies
/ blood
COVID-19
/ pathology
Chemokine CXCL10
/ biosynthesis
Comorbidity
Cytokines
/ blood
Exome
/ genetics
Female
Humans
Interferon-alpha
/ biosynthesis
Interferons
/ biosynthesis
Leukocytes, Mononuclear
/ immunology
Male
Middle Aged
SARS-CoV-2
/ immunology
Systemic Inflammatory Response Syndrome
/ pathology
Exome Sequencing
Young Adult
Interferon Lambda
SARS-CoV-2
coronavirus disease 2019
interferon
multisystem inflammatory syndrome
whole exome sequencing
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
06
2021
accepted:
12
08
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
30
9
2021
Statut:
epublish
Résumé
COVID-19 associated multisystem inflammatory syndrome (MIS) is a rare condition mostly affecting children but also adults (MIS-A). Although severe systemic inflammation and multiorgan dysfunction are hallmarks of the syndrome, the underlying pathogenesis is unclear. We aimed to provide novel immunological and genetic descriptions of MIS-A patients. Cytokine responses (IL-6, IL-1β, TNFα, CXCL10, type I, II and III interferons) following SARS-CoV-2 infection of peripheral blood mononuclear cells
Identifiants
pubmed: 34531865
doi: 10.3389/fimmu.2021.718744
pmc: PMC8439578
doi:
Substances chimiques
Autoantibodies
0
CXCL10 protein, human
0
Chemokine CXCL10
0
Cytokines
0
Interferon-alpha
0
adult multisystem inflammatory disease, COVID-19 related
0
Interferons
9008-11-1
Interferon Lambda
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
718744Informations de copyright
Copyright © 2021 Ronit, Jørgensen, Roed, Eriksson, Iepsen, Plovsing, Storgaard, Gustafsson, Hansen and Mogensen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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