A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
06 10 2021
Historique:
pubmed: 22 9 2021
medline: 4 3 2022
entrez: 21 9 2021
Statut: ppublish

Résumé

Triazole linkages (TLs) are mimics of the phosphodiester bond in oligonucleotides with applications in synthetic biology and biotechnology. Here we report the RuAAC-catalyzed synthesis of a novel 1,5-disubstituted triazole (TL

Identifiants

pubmed: 34546729
doi: 10.1021/jacs.1c08057
pmc: PMC8499026
doi:

Substances chimiques

Dinucleoside Phosphates 0
Triazoles 0
DNA 9007-49-2
DNA-Directed DNA Polymerase EC 2.7.7.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16293-16301

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R008655/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S018794/1
Pays : United Kingdom

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Auteurs

Sven Epple (S)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Aman Modi (A)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Ysobel R Baker (YR)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Ewa Wȩgrzyn (E)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Diallo Traoré (D)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Przemyslaw Wanat (P)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Agnes E S Tyburn (AES)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Arun Shivalingam (A)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Lapatrada Taemaitree (L)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Afaf H El-Sagheer (AH)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.
Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt.

Tom Brown (T)

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

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Classifications MeSH