Afaf H El-Sagheer

Affiliations

Chemistry Branch, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt.

Publications (38)

Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor.

Nucleic acids research

Avec: Anna Wypijewska Del Nogal , Anders F Füchtbauer , Mattias Bood , Jesper R Nilsson , Moa S Wranne , Sangamesh Sarangamath , Pauline Pfeiffer , Vinoth Sundar Rajan , Afaf H El-Sagheer , Anders Dahlén , Tom Brown , Morten Grøtli , L Marcus Wilhelmsson

Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells.

Cancer research

Avec: Mark R Jackson , Bas M Bavelaar , Philip A Waghorn , Martin R Gill , Afaf H El-Sagheer , Tom Brown , Madalena Tarsounas , Katherine A Vallis

A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility.

Journal of the American Chemical Society

Avec: Sven Epple , Aman Modi , Ysobel R Baker , Ewa Wȩgrzyn , Diallo Traoré , Przemyslaw Wanat , Agnes E S Tyburn , Arun Shivalingam , Lapatrada Taemaitree , Afaf H El-Sagheer , Tom Brown

Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking.

RSC medicinal chemistry

Avec: Joseph Hennessy , Piotr Klimkowski , Daniel Singleton , Alex Gibney , Malou Coche , Nicholas P Farrell , Afaf H El-Sagheer , Tom Brown , Andrew Kellett

Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages.

Organic letters

Avec: Belma Zengin Kurt , Debashis Dhara , Afaf H El-Sagheer , Tom Brown

A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids.

Chemical reviews

Avec: Nicolò Zuin Fantoni , Afaf H El-Sagheer , Tom Brown

Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids.

Chembiochem : a European journal of chemical biology

Avec: Alessandro Panattoni , Afaf H El-Sagheer , Tom Brown , Andrew Kellett , Michal Hocek

Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification.

Nucleic acids research

Avec: Ysobel R Baker , Liyiwen Yuan , Jinfeng Chen , Roman Belle , Robert Carlisle , Afaf H El-Sagheer , Tom Brown

Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides.

Journal of the American Chemical Society

Avec: Jeffrey Gorman , Sarah R E Orsborne , Akshay Sridhar , Raj Pandya , Peter Budden , Alexander Ohmann , Naitik A Panjwani , Yun Liu , Jake L Greenfield , Simon Dowland , Victor Gray , Seán T J Ryan , Sara De Ornellas , Afaf H El-Sagheer , Tom Brown , Jonathan R Nitschke , Jan Behrends , Ulrich F Keyser , Akshay Rao , Rosana Collepardo-Guevara , Eugen Stulz , Richard H Friend , Florian Auras

An Investigation into the Resistance of Spherical Nucleic Acids against DNA Enzymatic Degradation.

Bioconjugate chemistry

Avec: Maria-Eleni Kyriazi , Afaf H El-Sagheer , Igor L Medintz , Tom Brown , Antonios G Kanaras

A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide.

RSC advances

Avec: Konstantina Alexaki , Maria Eleni Kyriazi , Joshua Greening , Lapatrada Taemaitree , Afaf H El-Sagheer , Tom Brown , Xunli Zhang , Otto L Muskens , Antonios G Kanaras

Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications.

Nucleic acids research

Avec: Bríonna McGorman , Nicolò Zuin Fantoni , Sinéad O'Carroll , Anna Ziemele , Afaf H El-Sagheer , Tom Brown , Andrew Kellett

Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids.

Chembiochem : a European journal of chemical biology

Avec: Nicolò Zuin Fantoni , Bríonna McGorman , Zara Molphy , Daniel Singleton , Sarah Walsh , Afaf H El-Sagheer , Vickie McKee , Tom Brown , Andrew Kellett

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response.

Chemical communications (Cambridge, England)

Avec: Sven Epple , Cameron Thorpe , Ysobel R Baker , Afaf H El-Sagheer , Tom Brown

Molecular flexibility of DNA as a key determinant of RAD51 recruitment.

The EMBO journal

Avec: Federico Paoletti , Afaf H El-Sagheer , Jun Allard , Tom Brown , Omer Dushek , Fumiko Esashi

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.

Chemical communications (Cambridge, England)

Avec: Adam M Thomas , Sanja Brolih , Joanna F McGouran , Afaf H El-Sagheer , Denis Ptchelkine , Morgan Jones , Neil Q McDonald , Peter J McHugh , Tom Brown

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA.

Nature communications

Avec: Lapatrada Taemaitree , Arun Shivalingam , Afaf H El-Sagheer , Tom Brown

"Split-and-Click" sgRNA.

Methods in molecular biology (Clifton, N.J.)

Avec: Lapatrada Taemaitree , Arun Shivalingam , Afaf H El-Sagheer , Tom Brown

Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.

Emerging topics in life sciences

Avec: Sven Epple , Afaf H El-Sagheer , Tom Brown

Two-Step Validation Approach for Tools To Study the DNA Repair Enzyme SNM1A.

Chembiochem : a European journal of chemical biology

Avec: Ellen M Fay , Ailish Newton , Mark Berney , Afaf H El-Sagheer , Tom Brown , Joanna F McGouran

Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads.

RSC chemical biology

Avec: Cheng Jin , Siqi Li , Katherine A Vallis , Afaf H El-Sagheer , Tom Brown

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4.

ChemPlusChem

Avec: Anders F Füchtbauer , Moa S Wranne , Sangamesh Sarangamath , Mattias Bood , Afaf H El-Sagheer , Tom Brown , Henrik Gradén , Morten Grøtli , L Marcus Wilhelmsson

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting.

Organic & biomolecular chemistry

Avec: Piotr Klimkowski , Sara De Ornellas , Daniel Singleton , Afaf H El-Sagheer , Tom Brown

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

Journal of medicinal chemistry

Avec: Shifali Shishodia , Marina Demetriades , Dong Zhang , Nok Yin Tam , Pratheesh Maheswaran , Caitlin Clunie-O'Connor , Anthony Tumber , Ivanhoe K H Leung , Yi Min Ng , Thomas M Leissing , Afaf H El-Sagheer , Eidarus Salah , Tom Brown , Wei Shen Aik , Michael A McDonough , Christopher J Schofield

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.

Nature communications

Avec: Ysobel R Baker , Cameron Thorpe , Jinfeng Chen , Laura M Poller , Lina Cox , Pawan Kumar , Wooi F Lim , Lillian Lie , Graham McClorey , Sven Epple , Daniel Singleton , Michael A McDonough , Jack S Hardwick , Kirsten E Christensen , Matthew J A Wood , James P Hall , Afaf H El-Sagheer , Tom Brown

A new phosphoramidite enables orthogonal double labelling to form combination oligonucleotide probes.

Organic & biomolecular chemistry

Avec: Chunsen Bai , Piotr Klimkowski , Cheng Jin , Jagannath Kuchlyan , Afaf H El-Sagheer , Tom Brown

Synthesis, Biophysical and Biological Evaluation of Splice-Switching Oligonucleotides with Multiple LNA-Phosphothiotriester Backbones.

Journal of the American Chemical Society

Avec: Debashis Dhara , Alyssa C Hill , Abinaya Ramesh , Matthew J A Wood , Afaf H El-Sagheer , Tom Brown

Dynamics of the 4D genome during in vivo lineage specification and differentiation.

Nature communications

Avec: A Marieke Oudelaar , Robert A Beagrie , Matthew Gosden , Sara de Ornellas , Emily Georgiades , Jon Kerry , Daniel Hidalgo , Joana Carrelha , Arun Shivalingam , Afaf H El-Sagheer , Jelena M Telenius , Tom Brown , Veronica J Buckle , Merav Socolovsky , Douglas R Higgs , Jim R Hughes

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis.

Nucleic acids research

Avec: Jack S Hardwick , Marius M Haugland , Afaf H El-Sagheer , Denis Ptchelkine , Frank R Beierlein , Andrew N Lane , Tom Brown , Janet E Lovett , Edward A Anderson

Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly.

Angewandte Chemie (International ed. in English)

Avec: Arun Shivalingam , Lapatrada Taemaitree , Afaf H El-Sagheer , Tom Brown

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals.

ACS applied materials & interfaces

Avec: Maria Moros , Maria-Eleni Kyriazi , Afaf H El-Sagheer , Tom Brown , Claudia Tortiglione , Antonios G Kanaras

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices.

ACS nano

Avec: Angela F De Fazio , Afaf H El-Sagheer , Jason S Kahn , Iris Nandhakumar , Matthew Richard Burton , Tom Brown , Otto L Muskens , Oleg Gang , Antonios G Kanaras

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications.

Organic & biomolecular chemistry

Avec: Cameron Thorpe , Sven Epple , Benjamin Woods , Afaf H El-Sagheer , Tom Brown

An

Chemical science

Avec: Martin R Gill , Michael G Walker , Sarah Able , Ole Tietz , Abirami Lakshminarayanan , Rachel Anderson , Rod Chalk , Afaf H El-Sagheer , Tom Brown , Jim A Thomas , Katherine A Vallis

Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids.

ACS nano

Avec: Miguel Xavier , Maria-Eleni Kyriazi , Stuart Lanham , Konstantina Alexaki , Elloise Matthews , Afaf H El-Sagheer , Tom Brown , Antonios G Kanaras , Richard O C Oreffo

DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second.

ACS nano

Avec: Alisina Bazrafshan , Maria-Eleni Kyriazi , Brandon Alexander Holt , Wenxiao Deng , Selma Piranej , Hanquan Su , Yuesong Hu , Afaf H El-Sagheer , Tom Brown , Gabriel A Kwong , Antonios G Kanaras , Khalid Salaita

Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks.

Journal of the American Chemical Society

Avec: Sarah R E Orsborne , Jeffrey Gorman , Leah R Weiss , Akshay Sridhar , Naitik A Panjwani , Giorgio Divitini , Peter Budden , David Palecek , Seán T J Ryan , Akshay Rao , Rosana Collepardo-Guevara , Afaf H El-Sagheer , Tom Brown , Jan Behrends , Richard H Friend , Florian Auras

Synthesis of

ACS omega

Avec: Samir M El Rayes , Ibrahim A I Ali , Walid Fathalla , Mohamed A Ghanem , Afaf H El-Sagheer , Mohamed S Nafie

Réseau de co-auteurs

Tom Brown 37 collaborations

Antonios G Kanaras 6 collaborations

Sven Epple 5 collaborations

Arun Shivalingam 5 collaborations

Lapatrada Taemaitree 5 collaborations

Ysobel R Baker 4 collaborations

Daniel Singleton 4 collaborations

Andrew Kellett 4 collaborations

Maria-Eleni Kyriazi 4 collaborations

Katherine A Vallis 3 collaborations

Piotr Klimkowski 3 collaborations

Nicolò Zuin Fantoni 3 collaborations

Cameron Thorpe 3 collaborations

Anders F Füchtbauer 2 collaborations

Mattias Bood 2 collaborations

Moa S Wranne 2 collaborations

Sangamesh Sarangamath 2 collaborations

Morten Grøtli 2 collaborations

L Marcus Wilhelmsson 2 collaborations

Martin R Gill 2 collaborations

Debashis Dhara 2 collaborations

Jinfeng Chen 2 collaborations

Jeffrey Gorman 2 collaborations

Sarah R E Orsborne 2 collaborations

Akshay Sridhar 2 collaborations

Peter Budden 2 collaborations

Naitik A Panjwani 2 collaborations

Seán T J Ryan 2 collaborations

Sara De Ornellas 2 collaborations

Jan Behrends 2 collaborations

Akshay Rao 2 collaborations

Rosana Collepardo-Guevara 2 collaborations

Richard H Friend 2 collaborations

Florian Auras 2 collaborations

Konstantina Alexaki 2 collaborations

Otto L Muskens 2 collaborations

Bríonna McGorman 2 collaborations

Joanna F McGouran 2 collaborations

Denis Ptchelkine 2 collaborations

Cheng Jin 2 collaborations

Michael A McDonough 2 collaborations

Jack S Hardwick 2 collaborations

Matthew J A Wood 2 collaborations

Anna Wypijewska Del Nogal 1 collaboration

Jesper R Nilsson 1 collaboration

Pauline Pfeiffer 1 collaboration

Vinoth Sundar Rajan 1 collaboration

Anders Dahlén 1 collaboration

Mark R Jackson 1 collaboration

Bas M Bavelaar 1 collaboration

Philip A Waghorn 1 collaboration

Madalena Tarsounas 1 collaboration

Aman Modi 1 collaboration

Ewa Wȩgrzyn 1 collaboration

Diallo Traoré 1 collaboration

Przemyslaw Wanat 1 collaboration

Agnes E S Tyburn 1 collaboration

Joseph Hennessy 1 collaboration

Alex Gibney 1 collaboration

Malou Coche 1 collaboration

Nicholas P Farrell 1 collaboration

Belma Zengin Kurt 1 collaboration

Alessandro Panattoni 1 collaboration

Michal Hocek 1 collaboration

Liyiwen Yuan 1 collaboration

Roman Belle 1 collaboration

Robert Carlisle 1 collaboration

Raj Pandya 1 collaboration

Alexander Ohmann 1 collaboration

Yun Liu 1 collaboration

Jake L Greenfield 1 collaboration

Simon Dowland 1 collaboration

Victor Gray 1 collaboration

Jonathan R Nitschke 1 collaboration

Ulrich F Keyser 1 collaboration

Eugen Stulz 1 collaboration

Igor L Medintz 1 collaboration

Maria Eleni Kyriazi 1 collaboration

Joshua Greening 1 collaboration

Xunli Zhang 1 collaboration

Sinéad O'Carroll 1 collaboration

Anna Ziemele 1 collaboration

Zara Molphy 1 collaboration

Sarah Walsh 1 collaboration

Vickie McKee 1 collaboration

Federico Paoletti 1 collaboration

Jun Allard 1 collaboration

Omer Dushek 1 collaboration

Fumiko Esashi 1 collaboration

Adam M Thomas 1 collaboration

Sanja Brolih 1 collaboration

Morgan Jones 1 collaboration

Neil Q McDonald 1 collaboration

Peter J McHugh 1 collaboration

Ellen M Fay 1 collaboration

Ailish Newton 1 collaboration

Mark Berney 1 collaboration

Siqi Li 1 collaboration

Henrik Gradén 1 collaboration

Shifali Shishodia 1 collaboration

Marina Demetriades 1 collaboration

Dong Zhang 1 collaboration

Nok Yin Tam 1 collaboration

Pratheesh Maheswaran 1 collaboration

Caitlin Clunie-O'Connor 1 collaboration

Anthony Tumber 1 collaboration

Ivanhoe K H Leung 1 collaboration

Yi Min Ng 1 collaboration

Thomas M Leissing 1 collaboration

Eidarus Salah 1 collaboration

Wei Shen Aik 1 collaboration

Christopher J Schofield 1 collaboration

Laura M Poller 1 collaboration

Lina Cox 1 collaboration

Pawan Kumar 1 collaboration

Wooi F Lim 1 collaboration

Lillian Lie 1 collaboration

Graham McClorey 1 collaboration

Kirsten E Christensen 1 collaboration

James P Hall 1 collaboration

Chunsen Bai 1 collaboration

Jagannath Kuchlyan 1 collaboration

Alyssa C Hill 1 collaboration

Abinaya Ramesh 1 collaboration

A Marieke Oudelaar 1 collaboration

Robert A Beagrie 1 collaboration

Matthew Gosden 1 collaboration

Sara de Ornellas 1 collaboration

Emily Georgiades 1 collaboration

Jon Kerry 1 collaboration

Daniel Hidalgo 1 collaboration

Joana Carrelha 1 collaboration

Jelena M Telenius 1 collaboration

Veronica J Buckle 1 collaboration

Merav Socolovsky 1 collaboration

Douglas R Higgs 1 collaboration

Jim R Hughes 1 collaboration

Marius M Haugland 1 collaboration

Frank R Beierlein 1 collaboration

Andrew N Lane 1 collaboration

Janet E Lovett 1 collaboration

Edward A Anderson 1 collaboration

Maria Moros 1 collaboration

Claudia Tortiglione 1 collaboration

Angela F De Fazio 1 collaboration

Jason S Kahn 1 collaboration

Iris Nandhakumar 1 collaboration

Matthew Richard Burton 1 collaboration

Oleg Gang 1 collaboration

Benjamin Woods 1 collaboration

Michael G Walker 1 collaboration

Sarah Able 1 collaboration

Ole Tietz 1 collaboration

Abirami Lakshminarayanan 1 collaboration

Rachel Anderson 1 collaboration

Rod Chalk 1 collaboration

Jim A Thomas 1 collaboration

Miguel Xavier 1 collaboration

Stuart Lanham 1 collaboration

Elloise Matthews 1 collaboration

Richard O C Oreffo 1 collaboration

Alisina Bazrafshan 1 collaboration

Brandon Alexander Holt 1 collaboration

Wenxiao Deng 1 collaboration

Selma Piranej 1 collaboration

Hanquan Su 1 collaboration

Yuesong Hu 1 collaboration

Gabriel A Kwong 1 collaboration

Khalid Salaita 1 collaboration

Leah R Weiss 1 collaboration

Giorgio Divitini 1 collaboration

David Palecek 1 collaboration

Samir M El Rayes 1 collaboration

Ibrahim A I Ali 1 collaboration

Walid Fathalla 1 collaboration

Mohamed A Ghanem 1 collaboration

Mohamed S Nafie 1 collaboration