A scalable, secure, and interoperable platform for deep data-driven health management.

Big Data Computer Security Data Analysis Data Science / methods Health Information Interoperability Humans Information Storage and Retrieval Medical Records Systems, Computerized Software

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
01 10 2021
Historique:
received: 24 08 2020
accepted: 23 08 2021
entrez: 2 10 2021
pubmed: 3 10 2021
medline: 21 10 2021
Statut: epublish

Résumé

The large amount of biomedical data derived from wearable sensors, electronic health records, and molecular profiling (e.g., genomics data) is rapidly transforming our healthcare systems. The increasing scale and scope of biomedical data not only is generating enormous opportunities for improving health outcomes but also raises new challenges ranging from data acquisition and storage to data analysis and utilization. To meet these challenges, we developed the Personal Health Dashboard (PHD), which utilizes state-of-the-art security and scalability technologies to provide an end-to-end solution for big biomedical data analytics. The PHD platform is an open-source software framework that can be easily configured and deployed to any big data health project to store, organize, and process complex biomedical data sets, support real-time data analysis at both the individual level and the cohort level, and ensure participant privacy at every step. In addition to presenting the system, we illustrate the use of the PHD framework for large-scale applications in emerging multi-omics disease studies, such as collecting and visualization of diverse data types (wearable, clinical, omics) at a personal level, investigation of insulin resistance, and an infrastructure for the detection of presymptomatic COVID-19.

Identifiants

DOI: 10.1038/s41467-021-26040-1 PMID: 34599181 PMC: PMC8486823
pubmed: 34599181
doi: 10.1038/s41467-021-26040-1
pii: 10.1038/s41467-021-26040-1
pmc: PMC8486823
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5757

Subventions

Organisme : NIH HHS
ID : S10 OD023452
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Amir Bahmani (A)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Arash Alavi (A)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-7245-6889

Thore Buergel (T)

Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-1159-007X

Sushil Upadhyayula (S)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Qiwen Wang (Q)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Srinath Krishna Ananthakrishnan (SK)

Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Amir Alavi (A)

Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Diego Celis (D)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Dan Gillespie (D)

Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-0066-5136

Gregory Young (G)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Ziye Xing (Z)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.

Minh Hoang Huynh Nguyen (MHH)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.

Audrey Haque (A)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.

Ankit Mathur (A)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Josh Payne (J)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-1312-0138

Ghazal Mazaheri (G)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Jason Kenichi Li (JK)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Pramod Kotipalli (P)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Lisa Liao (L)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.

Rajat Bhasin (R)

Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Kexin Cha (K)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Benjamin Rolnik (B)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Alessandra Celli (A)

Department of Genetics, Stanford University, Stanford, CA, USA.

Orit Dagan-Rosenfeld (O)

Department of Genetics, Stanford University, Stanford, CA, USA.

Emily Higgs (E)

Department of Genetics, Stanford University, Stanford, CA, USA.

Wenyu Zhou (W)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.

Camille Lauren Berry (CL)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Katherine Grace Van Winkle (KG)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Kévin Contrepois (K)

Department of Genetics, Stanford University, Stanford, CA, USA.
ORCID: 0000-0001-9678-5161

Utsab Ray (U)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA.

Keith Bettinger (K)

Department of Genetics, Stanford University, Stanford, CA, USA.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA.

Somalee Datta (S)

Technology and Digital Solutions, Stanford Medicine, Stanford, CA, USA.

Xiao Li (X)

Department of Genetics, Stanford University, Stanford, CA, USA. xiao.li9@case.edu.
Department of Biochemistry, The Center for RNA Science and Therapeutics, Department of Computer and Data Sciences, Case Western Reserve University, Cleveland, OH, USA. xiao.li9@case.edu.

Michael P Snyder (MP)

Department of Genetics, Stanford University, Stanford, CA, USA. mpsnyder@stanford.edu.
Stanford Center for Genomics and Personalized Medicine, Stanford University, Stanford, CA, USA. mpsnyder@stanford.edu.
Stanford Healthcare Innovation Lab, Stanford University, Stanford, CA, USA. mpsnyder@stanford.edu.
ORCID: 0000-0003-0784-7987

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Systèmes d'information › Mégadonnées › A scalable, secure, and interoperable platform...
questionsmedicales.fr › Administration des services de santé › Organisation et administration › Mesures de sécurité › Sécurité informatique › A scalable, secure, and interoperable platform...
questionsmedicales.fr › Disciplines des sciences naturelles › Mathématiques › Analyse de données › A scalable, secure, and interoperable platform...
questionsmedicales.fr › Sciences de l'information › Science des données › A scalable, secure, and interoperable platform...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Interopérabilité des informations de santé › A scalable, secure, and interoperable platform...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A scalable, secure, and interoperable platform...
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