Immunomodulatory effect of metabolites from digested and fermented fractions from irradiated pineapple (Annanas comosus L.) snack-bars.
Cyclooxygenase 2
Immunomodulatory effect
Phenolic compounds
Pineapple bars
TNF-α
Journal
Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639
Informations de publication
Date de publication:
30 Mar 2022
30 Mar 2022
Historique:
received:
29
08
2021
revised:
05
10
2021
accepted:
06
10
2021
pubmed:
7
11
2021
medline:
15
12
2021
entrez:
6
11
2021
Statut:
ppublish
Résumé
Phenolic compounds (PC), can modulate the immune response. UV-C irradiation, commonly used as a minimal processing method in fresh-foods to reduce the microbial load, increase shelf-life, provide a minimal processing and facilitate the release of PC. This study aimed to evaluate the effect of intestinal (IF) and fermented (FF) fractions of non-irradiated (NIPB) and irradiated (IPB) pineapple snack-bars on the production of nitric oxide (NO), interleukin 6 (IL-6), cyclooxygenase 2 (COX-2), and tumor necrosis factor-alpha (TNF-α) in mice macrophages. IF of NIPB and IPB exerted an immunomodulatory effect by promoting the production of NO (26 pg/mL) in both treatments, COX-2 (438 and 399 pg/mL), and TNF-α (778 and 802 pg/mL) for NIPB and IPB respectively. The TNF-α increased in IF of NIPB and IPB approximately 371 %, and in FF, only increased 132 %. The NO production was not different between IF and FF. COX-2 production was higher in FF.
Identifiants
pubmed: 34742041
pii: S0308-8146(21)02381-5
doi: 10.1016/j.foodchem.2021.131375
pii:
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Nitric Oxide
31C4KY9ESH
Cyclooxygenase 2
EC 1.14.99.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
131375Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.