Strategies for targeting cell surface proteins using multivalent conjugates and chemical biology.
Antibody
Antibody-drug conjugate
Bispecific
Chemical biology
GPCR
Nanobody
Receptor
VHH
Journal
Methods in cell biology
ISSN: 0091-679X
Titre abrégé: Methods Cell Biol
Pays: United States
ID NLM: 0373334
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
9
11
2021
pubmed:
10
11
2021
medline:
8
4
2022
Statut:
ppublish
Résumé
Proper function of receptors on the cell surface is essential for homeostasis. Compounds that target cell surface receptors to address dysregulation have proven exceptionally successful as therapeutic agents; however, the development of compounds with the desired specificity for receptors, cells, and tissues of choice has proven difficult in some cases. The use of compounds that can engage more than one binding site at the cell surface offers a path toward improving biological specificity or pharmacological properties. In this chapter we summarize historical context for the development of such bivalent compounds. We focus on developments in chemical methods and biological engineering to provide bivalent compounds in which the high affinity and specificity of antibodies are leveraged to create multifunctional conjugates with new and useful properties. The development of methods to meld biological macromolecules with synthetic compounds will facilitate modulation of receptor biology in ways not previously possible.
Identifiants
pubmed: 34752333
pii: S0091-679X(21)00047-9
doi: 10.1016/bs.mcb.2021.06.004
pmc: PMC8895325
mid: NIHMS1776849
pii:
doi:
Substances chimiques
Antibodies, Bispecific
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-222Subventions
Organisme : Intramural NIH HHS
ID : Z99 DK999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK075157
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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