Type I interferon activates MHC class I-dressed CD11b

Animals Antigens, Neoplasm / immunology CD11b Antigen / immunology CD8-Positive T-Lymphocytes / immunology Cross-Priming Dendritic Cells / drug effects Histocompatibility Antigens Class I / immunology Interferon Type I / immunology Interferon-beta / administration & dosage Lymphocytes, Tumor-Infiltrating / immunology Mice Neoplasms / immunology Receptors, Interferon / immunology Signal Transduction / immunology Tumor Microenvironment / immunology
MHC class I dressing T cell exhaustion anti-tumor immunity cross-presentation dendritic cells immunotherapy optimal anti-tumor immunity tumor regression type 2 dendritic cells type I interferon

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
08 02 2022
Historique:
received: 21 04 2021
revised: 31 07 2021
accepted: 22 10 2021
pubmed: 21 11 2021
medline: 15 3 2022
entrez: 20 11 2021
Statut: ppublish

Résumé

Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing tumors. Tumor-reactive CD8

Identifiants

DOI: 10.1016/j.immuni.2021.10.020 PMID: 34800368
pubmed: 34800368
pii: S1074-7613(21)00458-1
doi: 10.1016/j.immuni.2021.10.020
pii:
doi:

Substances chimiques

Antigens, Neoplasm 0
CD11b Antigen 0
Histocompatibility Antigens Class I 0
Interferon Type I 0
Itgam protein, mouse 0
Receptors, Interferon 0
Interferon-beta 77238-31-4

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

308-323.e9

Subventions

Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests. Part of this work contributed to the US patent 17/348,704 with E.D. and S.S. as inventors. S.S. is a co-founder of Danger Bio and a consultant or SAB member of Arcus Biosciences, Dragonfly Therapeutics, TAKEDA, Merck, Ribon Therapeutics, and Tango Therapeutics. These activities are not in conflict with the presented data.

Auteurs

Ellen Duong (E)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA; Department of Biology, MIT, Cambridge, MA, USA.

Tim B Fessenden (TB)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA.

Emi Lutz (E)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA; Department of Biological Engineering, MIT, Cambridge, MA, USA.

Teresa Dinter (T)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA; Department of Biology, MIT, Cambridge, MA, USA.

Leon Yim (L)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA.

Sarah Blatt (S)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA.

Arjun Bhutkar (A)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA.

Karl Dane Wittrup (KD)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA; Department of Biological Engineering, MIT, Cambridge, MA, USA.

Stefani Spranger (S)

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA; Department of Biology, MIT, Cambridge, MA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Electronic address: spranger@mit.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Antigènes CD11 › Antigènes CD11b › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Cross-priming › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe I › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Interféron bêta › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes TIL › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Tumeurs › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteur interféron › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Type I interferon activates MHC class I-dressed CD11b
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Type I interferon activates MHC class I-dressed CD11b