Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.
Aged
Aspartic Acid
/ analogs & derivatives
Behavior
Cognition
Executive Function
Female
Frontotemporal Lobar Degeneration
/ metabolism
Glutamates
/ metabolism
Humans
Male
Middle Aged
Prefrontal Cortex
/ metabolism
Primary Visual Cortex
/ metabolism
Proton Magnetic Resonance Spectroscopy
Temporal Lobe
/ metabolism
Behavioral variant frontotemporal dementia
Corticobasal syndrome
Frontotemporal lobar degeneration
Glutamate
Progressive supranuclear palsy
spectroscopy
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
19
05
2021
revised:
11
10
2021
accepted:
23
10
2021
pubmed:
1
1
2022
medline:
22
2
2022
entrez:
31
12
2021
Statut:
ppublish
Résumé
There is an urgent need for a better understanding of the pathophysiology of cognitive impairment in syndromes associated with frontotemporal lobar degeneration. Here, we used magnetic resonance spectroscopy to quantify metabolite deficits in sixty patients with a clinical syndrome associated with frontotemporal lobar degeneration (behavioral variant frontotemporal dementia n = 11, progressive supranuclear palsy n = 26, corticobasal syndrome n = 11, primary progressive aphasias n = 12), and 38 age- and sex-matched healthy controls. We measured nine metabolites in the right inferior frontal gyrus, superior temporal gyrus and right primary visual cortex. Metabolite concentrations were corrected for age, sex, and partial volume then compared with cognitive and behavioral measures using canonical correlation analysis. Metabolite concentrations varied significantly by brain region and diagnosis (region x metabolite x diagnosis interaction F
Identifiants
pubmed: 34971846
pii: S0197-4580(21)00324-9
doi: 10.1016/j.neurobiolaging.2021.10.012
pmc: PMC8776136
mid: EMS140676
pii:
doi:
Substances chimiques
Glutamates
0
Aspartic Acid
30KYC7MIAI
N-acetylaspartate
997-55-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-70Subventions
Organisme : Wellcome Trust
ID : 103838
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009041/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : SUAG/051 G101400
Pays : United Kingdom
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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