RNA gradients: Shapers of 3D genome architecture.

Cell Nucleus / metabolism Chromatin / metabolism Eukaryotic Cells Genome / genetics RNA / genetics

Journal

Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428

Informations de publication

Date de publication:
02 2022
Historique:
received: 17 11 2021
revised: 01 12 2021
accepted: 03 12 2021
pubmed: 9 1 2022
medline: 4 5 2022
entrez: 8 1 2022
Statut: ppublish

Résumé

A growing body of evidence points to a role of nuclear RNAs (nucRNAs) in shaping the three-dimensional (3D) architecture of the genome within the nucleus of a eukaryotic cell. nucRNAs are non-homogeneously distributed within the nucleus where they can form global and local gradients that might contribute to instructing the formation and coordinating the function of different types of 3D genome structures. In this article, we highlight the available literature supporting a role of nucRNAs as 3D genome shapers and propose that nucRNA gradients are key mediators of genome structure and function.

Identifiants

DOI: 10.1016/j.ceb.2021.12.001 PMID: 34998095
pubmed: 34998095
pii: S0955-0674(21)00117-4
doi: 10.1016/j.ceb.2021.12.001
pii:
doi:

Substances chimiques

Chromatin 0
RNA 63231-63-0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7-12

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Britta A M Bouwman (BAM)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17165, Sweden; Science for Life Laboratory, Solna, 17165, Sweden. Electronic address: britta.bouwman@scilifelab.se.

Nicola Crosetto (N)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17165, Sweden; Science for Life Laboratory, Solna, 17165, Sweden.

Magda Bienko (M)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17165, Sweden; Science for Life Laboratory, Solna, 17165, Sweden. Electronic address: magda.bienko@scilifelab.se.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › RNA gradients: Shapers of 3D genome architecture.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › RNA gradients: Shapers of 3D genome architecture.
questionsmedicales.fr › Cellules › Cellules eucaryotes › RNA gradients: Shapers of 3D genome architecture.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › RNA gradients: Shapers of 3D genome architecture.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › RNA gradients: Shapers of 3D genome architecture.