RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival.
Apoptosis Regulatory Proteins
/ genetics
Cell Line, Tumor
Cell Survival
Exosome Multienzyme Ribonuclease Complex
/ genetics
Exosomes
/ metabolism
Gene Amplification
Gene Expression Regulation, Neoplastic
Humans
Mitochondrial Proteins
/ genetics
Neoplasms
/ genetics
Nuclear Proteins
/ genetics
Pancreatic Neoplasms
/ diagnosis
Prognosis
RNA, Messenger
/ metabolism
RNA-Binding Proteins
/ genetics
RNA-Seq
EXOSC4
PanCancer
RNA exosome
TCGA
cell survival
gene amplification
pancreatic cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Jan 2022
02 Jan 2022
Historique:
received:
30
11
2021
revised:
26
12
2021
accepted:
30
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
27
1
2022
Statut:
epublish
Résumé
The RNA exosome is a multi-subunit ribonuclease complex that is evolutionally conserved and the major cellular machinery for the surveillance, processing, degradation, and turnover of diverse RNAs essential for cell viability. Here we performed integrated genomic and clinicopathological analyses of 27 RNA exosome components across 32 tumor types using The Cancer Genome Atlas PanCancer Atlas Studies' datasets. We discovered that the
Identifiants
pubmed: 35008922
pii: ijms23010496
doi: 10.3390/ijms23010496
pmc: PMC8745236
pii:
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
BIK protein, human
0
Mitochondrial Proteins
0
Nuclear Proteins
0
RNA, Messenger
0
RNA-Binding Proteins
0
SESN2 protein, human
0
EXOSC4 protein, human
EC 3.1.-
Exosome Multienzyme Ribonuclease Complex
EC 3.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17KK0163, 18H02570, 18KT0016, 20H03655, 20H04838, 21H04792, 21H00243, 21H02758, 21K19402
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