Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice.

Animals Disease Progression Escherichia coli Infections / complications Haptoglobins / genetics Heme Hemoglobins Hemolysis Hemolytic-Uremic Syndrome / complications Hemopexin Mice Shiga Toxin Shiga-Toxigenic Escherichia coli Thrombotic Microangiopathies / etiology
Shiga toxin acute kidney injury haptoglobin hemolysis hemolytic-uremic syndrome hemopexin iron homeostasis

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
06 2022
Historique:
received: 23 02 2021
revised: 05 12 2021
accepted: 16 12 2021
pubmed: 16 1 2022
medline: 25 5 2022
entrez: 15 1 2022
Statut: ppublish

Résumé

Thrombotic microangiopathy, hemolysis and acute kidney injury are typical clinical characteristics of hemolytic-uremic syndrome (HUS), which is predominantly caused by Shiga-toxin-producing Escherichia coli. Free heme aggravates organ damage in life-threatening infections, even with a low degree of systemic hemolysis. Therefore, we hypothesized that the presence of the hemoglobin- and the heme-scavenging proteins, haptoglobin and hemopexin, respectively impacts outcome and kidney pathology in HUS. Here, we investigated the effect of haptoglobin and hemopexin deficiency (haptoglobin

Identifiants

DOI: 10.1016/j.kint.2021.12.024 PMID: 35031328
pubmed: 35031328
pii: S0085-2538(22)00016-3
doi: 10.1016/j.kint.2021.12.024
pii:
doi:

Substances chimiques

Haptoglobins 0
Hemoglobins 0
Heme 42VZT0U6YR
Shiga Toxin 75757-64-1
Hemopexin 9013-71-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1171-1185

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Wiebke Pirschel (W)

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Center, Jena University Hospital, Jena, Germany.

Antonio N Mestekemper (AN)

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Center, Jena University Hospital, Jena, Germany.

Bianka Wissuwa (B)

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Center, Jena University Hospital, Jena, Germany.

Nadine Krieg (N)

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Center, Jena University Hospital, Jena, Germany.

Sarah Kröller (S)

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Center, Jena University Hospital, Jena, Germany.

Christoph Daniel (C)

Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Florian Gunzer (F)

Department of Hospital Infection Control, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.

Emanuela Tolosano (E)

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

Michael Bauer (M)

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.

Kerstin Amann (K)

Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Stefan H Heinemann (SH)

Center of Molecular Biomedicine (CMB), Department of Biophysics, Friedrich Schiller University Jena, Jena, Germany; Center of Molecular Biomedicine (CMB), Department of Biophysics, Jena University Hospital, Jena, Germany.

Sina M Coldewey (SM)

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Center, Jena University Hospital, Jena, Germany; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. Electronic address: sina.coldewey@med.uni-jena.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Escherichia coli › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Mucoprotéines › Haptoglobines › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Globines › Hémoglobines › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Phénomènes du système immunitaire › Réaction antigène-anticorps › Hémolyse › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Anomalies des plaquettes › Thrombopénie › Microangiopathies thrombotiques › Syndrome hémolytique et urémique › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Hémopexine › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Entérotoxines › Shiga-toxines › Shiga-toxine › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli producteur de Shiga-toxine › Divergent roles of haptoglobin and hemopexin...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Anomalies des plaquettes › Thrombopénie › Microangiopathies thrombotiques › Divergent roles of haptoglobin and hemopexin...