Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8
Adult
Aged
Aged, 80 and over
Aging
/ immunology
Apoptosis
CD8-Positive T-Lymphocytes
/ immunology
COVID-19
/ immunology
Cancer Vaccines
/ immunology
Cell Division
Female
Fenofibrate
/ pharmacology
Glucose
/ metabolism
HLA-A2 Antigen
/ immunology
Humans
Hypolipidemic Agents
/ pharmacology
Immunocompetence
/ drug effects
Influenza, Human
/ immunology
Lipid Metabolism
/ drug effects
Lymphocyte Activation
MART-1 Antigen
/ chemistry
Male
Middle Aged
Neoplasms
/ immunology
Peptide Fragments
/ immunology
Rosiglitazone
/ pharmacology
Single-Blind Method
Vaccination
Viral Vaccines
/ immunology
Young Adult
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
received:
26
02
2021
accepted:
24
11
2021
pubmed:
16
1
2022
medline:
27
1
2022
entrez:
15
1
2022
Statut:
ppublish
Résumé
Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered Ags. The mechanisms that underlie this phenomenon have nonetheless remained unclear. We found that naive CD8
Identifiants
pubmed: 35031578
pii: jimmunol.2100194
doi: 10.4049/jimmunol.2100194
pmc: PMC7615155
mid: EMS181810
doi:
Substances chimiques
Cancer Vaccines
0
HLA-A2 Antigen
0
Hypolipidemic Agents
0
MART-1 Antigen
0
MLANA protein, human
0
Peptide Fragments
0
Viral Vaccines
0
Rosiglitazone
05V02F2KDG
Glucose
IY9XDZ35W2
Fenofibrate
U202363UOS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
562-570Subventions
Organisme : Wellcome Trust
ID : 100326
Pays : United Kingdom
Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.
Références
Aging Cell. 2016 Feb;15(1):128-39
pubmed: 26522807
Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S121-5
pubmed: 11041083
Immunity. 2017 Mar 21;46(3):405-420
pubmed: 28314591
Exp Gerontol. 2014 Jun;54:75-83
pubmed: 24468331
AIDS. 2018 Mar 13;32(5):575-581
pubmed: 29280760
J Intern Med. 2018 Feb;283(2):110-120
pubmed: 29071761
Nat Immunol. 2016 Aug;17(8):966-75
pubmed: 27270402
Cancer Cell. 2017 Sep 11;32(3):377-391.e9
pubmed: 28898698
Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):371-5
pubmed: 10471124
Semin Immunol. 2016 Oct;28(5):514-524
pubmed: 27825556
Front Immunol. 2015 Jan 22;6:1
pubmed: 25657648
JCI Insight. 2017 Feb 9;2(3):e89160
pubmed: 28194435
JCI Insight. 2018 Jul 12;3(13):
pubmed: 29997288
Comput Struct Biotechnol J. 2014 Nov 15;13:38-46
pubmed: 25750699
J Immunol. 2017 Jun 1;198(11):4205-4209
pubmed: 28432147
Clin Mol Allergy. 2017 Dec 14;15:21
pubmed: 29259496
Elife. 2015 Nov 14;4:
pubmed: 26568315
Diabetes. 2007 Apr;56(4):1143-52
pubmed: 17259370
Front Immunol. 2014 Oct 13;5:483
pubmed: 25352844
Immunol Rev. 2018 May;283(1):213-231
pubmed: 29664569
J Cell Physiol. 2012 Jan;227(1):339-50
pubmed: 21437903
Front Immunol. 2021 Jul 13;12:693054
pubmed: 34326844
Front Immunol. 2018 Oct 25;9:2372
pubmed: 30410483
Aging Cell. 2020 Nov;19(11):e13267
pubmed: 33219735
J Immunol. 2014 Mar 1;192(5):2143-55
pubmed: 24501199
Longev Healthspan. 2013 May 02;2(1):8
pubmed: 24472098
Aging Dis. 2015 Mar 10;6(2):109-20
pubmed: 25821639
Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15;303(8):G979-92
pubmed: 22899824
J Immunol. 2018 Jan 15;200(2):643-656
pubmed: 29237780
J Immunol. 2015 May 1;194(9):4073-80
pubmed: 25888703
Front Immunol. 2018 Jan 10;8:1960
pubmed: 29375577
Curr Opin Immunol. 2009 Aug;21(4):404-7
pubmed: 19632102
J Immunol. 2012 Dec 15;189(12):5541-8
pubmed: 23136199
Molecules. 2016 Dec 15;21(12):
pubmed: 27983708
Trends Mol Med. 2018 Jan;24(1):30-48
pubmed: 29246759
J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1192-200
pubmed: 21835806
J Immunol. 2016 Jan 1;196(1):256-263
pubmed: 26608912
Geroscience. 2020 Aug;42(4):1015-1019
pubmed: 32583231
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Cell. 2013 Jun 6;153(6):1239-51
pubmed: 23746840
Clin Nutr. 2006 Dec;25(6):1004-14
pubmed: 16859815
Nature. 2009 Jul 2;460(7251):103-7
pubmed: 19494812
Cell Death Dis. 2017 Feb 16;8(2):e2615
pubmed: 28206987
Cancer Immunol Res. 2018 Nov;6(11):1375-1387
pubmed: 30143538
Curr Opin Immunol. 2017 Jun;46:1-7
pubmed: 28359913
Nat Immunol. 2013 Oct;14(10):1064-72
pubmed: 23955661
J Immunol. 2014 Sep 15;193(6):2622-9
pubmed: 25193936
Immunity. 2014 Jul 17;41(1):75-88
pubmed: 25001241
Immunity. 2017 Mar 21;46(3):488-503
pubmed: 28285833
JCI Insight. 2019 Apr 4;4(7):
pubmed: 30944257
J Exp Med. 2005 Nov 21;202(10):1349-61
pubmed: 16287711
Front Immunol. 2018 Dec 21;9:2736
pubmed: 30619240
PPAR Res. 2008;2008:547470
pubmed: 18509487
Aging Cell. 2016 Feb;15(1):14-21
pubmed: 26472076
Nat Commun. 2016 Nov 30;7:13683
pubmed: 27901044
J Biol Chem. 2009 Nov 13;284(46):31735-45
pubmed: 19740747
Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1736-45
pubmed: 17848638