Lactic acid, a driver of tumor-stroma interactions.

Endothelial Cells Glycolysis Lactic Acid Oxidative Phosphorylation Stromal Cells Tumor Microenvironment
Lactic acid Tumor-associated adipocytes Tumor-associated fibroblasts Tumor-associated macrophages Tumor-associated vascular endothelial cells

Journal

International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259

Informations de publication

Date de publication:
May 2022
Historique:
received: 20 12 2021
revised: 23 01 2022
accepted: 27 01 2022
pubmed: 9 2 2022
medline: 7 4 2022
entrez: 8 2 2022
Statut: ppublish

Résumé

Warburg effect is one of the hallmarks of tumor favoring the suppression of normal oxidative phosphorylation (OxPhos) and the adaptation to hypoxia. In addition to providing continuous energy to meet the demands of tumors, acceleratedWarburg effect also producesa large amount of lactic acid. Lactic acid shuttles between different cell populations within the tumor microenvironment (TME) and confers tumor cells to interact with surrounding cells, which has emerged as a new phenomenon in the field of tumor biology and tumorigenesis. Lactic acid not only fulfills the energetic demands of stromal cells, but becomes a major regulator of their activity by serving as a signaling molecule. Activated stromal cells in turn support tumor development. In this review, we discuss the role of lactic acid in transformation and oncogenic function of stromal cells including fibroblasts, macrophages, adipocytes and vascular endothelial cells, and suggest the relevance of lactic acid in therapy response and essential questions in this field.

Identifiants

DOI: 10.1016/j.intimp.2022.108597 PMID: 35131570
pubmed: 35131570
pii: S1567-5769(22)00081-9
doi: 10.1016/j.intimp.2022.108597
pii:
doi:

Substances chimiques

Lactic Acid 33X04XA5AT

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

108597

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Dun Niu (D)

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.

Yiwen Wu (Y)

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.

Ziyao Lei (Z)

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China.

Ming Zhang (M)

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China.

Zhizhong Xie (Z)

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China. Electronic address: zhizhongx@126.com.

Shengsong Tang (S)

Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, Hunan University of Medicine, Huaihua 418000, China. Electronic address: tangss111@163.com.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Lactic acid, a driver of tumor-stroma interactions.
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Lactic acid, a driver of tumor-stroma interactions.
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Lactic acid, a driver of tumor-stroma interactions.
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphorylation oxydative › Lactic acid, a driver of tumor-stroma interactions.
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Cellules stromales › Lactic acid, a driver of tumor-stroma interactions.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Lactic acid, a driver of tumor-stroma interactions.