Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin
3-phenylcoumarin
3D-QSAR models
molecular docking
molecular dynamics
monoamine oxidase B inhibitors
trans-6-styrylcoumarin
trans-resveratrol
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Jan 2022
29 Jan 2022
Historique:
received:
28
12
2021
revised:
25
01
2022
accepted:
28
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in the central nervous system, as well as the production of reactive oxygen species. Molecules that act selectively on one of the MAO isoforms have been studied deeply, and coumarin has been described as a promising scaffold. In the current manuscript we describe a comparative study between 3-phenylcoumarin (
Identifiants
pubmed: 35164192
pii: molecules27030928
doi: 10.3390/molecules27030928
pmc: PMC8838197
pii:
doi:
Substances chimiques
Coumarins
0
Monoamine Oxidase Inhibitors
0
Styrenes
0
coumarin
A4VZ22K1WT
Monoamine Oxidase
EC 1.4.3.4
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agencia Nacional de Investigación y Desarrollo
ID : Fondecyt Postdoctoral Grant 3180408
Organisme : Vicerrectoría de Investigación y Estudios Avanzados of Pontificia Universidad Católica de Valparaíso
ID : VRIEA-PUCV 37.0/2017
Organisme : Ministerio de Ciencia e Innovación
ID : PID2020-116076RJ-I00/AEI/10.13039/501100011033
Organisme : Fundação para a Ciência e Tecnologia
ID : CEECIND/02423/2018 and UIDB/00081/2020
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