Desmoglein 2 can undergo Ca
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
05 04 2022
05 04 2022
Historique:
received:
01
07
2021
revised:
23
08
2021
accepted:
15
02
2022
pubmed:
21
2
2022
medline:
9
4
2022
entrez:
20
2
2022
Statut:
ppublish
Résumé
Desmoglein (Dsg) 2 is a ubiquitously expressed desmosomal cadherin. Particularly, it is present in all cell types forming desmosomes, including epithelial cells and cardiac myocytes and is upregulated in the autoimmune skin disease pemphigus. Thus, we here characterized the binding properties of Dsg2 in more detail using atomic force microscopy (AFM). Dsg2 exhibits homophilic interactions and also heterophilic interactions with the desmosomal cadherin desmocollin (Dsc) 2, and further with the classical cadherins E-cadherin (E-Cad) and N-cadherin (N-Cad), which may be relevant for cross talk between desmosomes and adherens junctions in epithelia and cardiac myocytes. We found that all homo- and heterophilic interactions were Ca
Identifiants
pubmed: 35183520
pii: S0006-3495(22)00147-3
doi: 10.1016/j.bpj.2022.02.023
pmc: PMC9034291
pii:
doi:
Substances chimiques
Cadherins
0
Desmoglein 2
0
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1322-1335Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
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