A Velvet Transcription Factor Specifically Activates Mating through a Novel Mating-Responsive Protein in the Human Fungal Pathogen Cryptococcus deneoformans.

Cryptococcus neoformans / genetics Fungal Proteins / genetics Genes, Mating Type, Fungal Meiosis Transcription Factors / genetics
Cryptococcus cell-cell fusion mating sexual reproduction velvet protein family

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
29 06 2022
Historique:
pubmed: 27 4 2022
medline: 2 7 2022
entrez: 26 4 2022
Statut: ppublish

Résumé

Sexual reproduction facilitates infection by the production of both a lineage advantage and infectious sexual spores in the ubiquitous human fungal pathogen Cryptococcus deneoformans. However, the regulatory determinants specific for initiating mating remain poorly understood. Here, we identified a velvet family regulator, Cva1, that strongly promotes sexual reproduction in C. deneoformans. This regulation was determined to be specific, based on a comprehensive phenotypic analysis of

Identifiants

DOI: 10.1128/spectrum.02653-21 PMID: 35471092 PMC: PMC9241590
pubmed: 35471092
doi: 10.1128/spectrum.02653-21
pmc: PMC9241590
doi:

Substances chimiques

Fungal Proteins 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0265321

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Auteurs

Huimin Liu (H)

School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Xiaoxia Yao (X)

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.

Weixin Ke (W)

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.

Hao Ding (H)

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.

Guang-Jun He (GJ)

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Shuang Ma (S)

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Yan Peng (Y)

College of Pharmaceutical Sciences, Medical Research Institute, Southwest University, Chongqing, China.

Xinping Xu (X)

Jiangxi Institute of Respiratory Disease, The First Affiliated Hospital of Nanchang University, Jiangxi, China.

Guojian Liao (G)

College of Pharmaceutical Sciences, Medical Research Institute, Southwest University, Chongqing, China.

Xiuyun Tian (X)

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

Linqi Wang (L)

School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
ORCID: 0000-0002-5243-341X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Levures › Cryptococcus › Cryptococcus neoformans › A Velvet Transcription Factor Specifically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › A Velvet Transcription Factor Specifically...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome fongique › Gènes fongiques › Gènes fongiques du type conjugant › A Velvet Transcription Factor Specifically...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Méiose › A Velvet Transcription Factor Specifically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › A Velvet Transcription Factor Specifically...