MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
02
2022
accepted:
15
04
2022
entrez:
28
4
2022
pubmed:
29
4
2022
medline:
3
5
2022
Statut:
epublish
Résumé
MafB (a bZIP transcription factor), ß-catenin (the ultimate target of the Wnt signal transduction pathway that acts as a transcriptional co-activator of LEF/TCF proteins), and WDR77 (a transcriptional co-activator of multiple hormone receptors) are important for breast cellular transformation. Unexpectedly, these proteins interact directly with each other, and they have similar genomic binding profiles. Furthermore, while some of these common target sites coincide with those bound by LEF/TCF, the majority are located just downstream of transcription initiation sites at a position near paused RNA polymerase (Pol II) and the +1 nucleosome. Occupancy levels of these factors at these promoter-proximal sites are strongly correlated with the level of paused Pol II and transcriptional activity.
Identifiants
pubmed: 35482762
doi: 10.1371/journal.pone.0264799
pii: PONE-D-22-04674
pmc: PMC9049301
doi:
Substances chimiques
Catenins
0
Transcription Factors
0
beta Catenin
0
RNA Polymerase II
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0264799Subventions
Organisme : NCI NIH HHS
ID : R01 CA107486
Pays : United States
Déclaration de conflit d'intérêts
No, there is no conflict of interest. My manuscript contains the following statement: "The authors declare that they have no conflict of interest."
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