Secondary Metabolism Gene Clusters Exhibit Increasingly Dynamic and Differential Expression during Asexual Growth, Conidiation, and Sexual Development in Neurospora crassa.
Neurospora crassa
asexual development
environmental microbiology
filamentous fungi
gene cluster
secondary metabolism
sexual development
transcriptomics
Journal
mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
pubmed:
1
6
2022
medline:
1
6
2022
entrez:
31
5
2022
Statut:
ppublish
Résumé
Secondary metabolite clusters (SMCs) encode the machinery for fungal toxin production. However, understanding their function and analyzing their products requires investigation of the developmental and environmental conditions in which they are expressed. Gene expression is often restricted to specific and unexamined stages of the life cycle. Therefore, we applied comparative genomics analyses to identify SMCs in Neurospora crassa and analyzed extensive transcriptomic data spanning nine independent experiments from diverse developmental and environmental conditions to reveal their life cycle-specific gene expression patterns. We reported 20 SMCs comprising 177 genes-a manageable set for investigation of the roles of SMCs across the life cycle of the fungal model N. crassa-as well as gene sets coordinately expressed in 18 predicted SMCs during asexual and sexual growth under three nutritional and two temperature conditions. Divergent activity of SMCs between asexual and sexual development was reported. Of 126 SMC genes that we examined for knockout phenotypes,
Identifiants
pubmed: 35638725
doi: 10.1128/msystems.00232-22
pmc: PMC9239088
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e0023222Subventions
Organisme : NIAID NIH HHS
ID : R01 AI146584
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
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