Helena's Many Daughters: More Mitogenome Diversity behind the Most Common West Eurasian mtDNA Control Region Haplotype in an Extended Italian Population Sample.

DNA, Mitochondrial / genetics Genetics, Population Genome, Mitochondrial Haplotypes / genetics Nuclear Family Pilot Projects Sequence Analysis, DNA
forensics massively parallel sequencing most common haplotype mtDNA haplogroup H next-generation sequencing power of discrimination random match probability

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
16 Jun 2022
Historique:
received: 24 05 2022
revised: 13 06 2022
accepted: 14 06 2022
entrez: 24 6 2022
pubmed: 25 6 2022
medline: 28 6 2022
Statut: epublish

Résumé

The high number of matching haplotypes of the most common mitochondrial (mt)DNA lineages are considered to be the greatest limitation for forensic applications. This study investigates the potential to solve this constraint by massively parallel sequencing a large number of mitogenomes that share the most common West Eurasian mtDNA control region (CR) haplotype motif (263G 315.1C 16519C). We augmented a pilot study on 29 to a total of 216 Italian mitogenomes that represents the largest set of the most common CR haplotype compiled from a single country. The extended population sample confirmed and extended the huge coding region diversity behind the most common CR motif. Complete mitogenome sequencing allowed for the detection of 163 distinct haplotypes, raising the power of discrimination from 0 (CR) to 99.6% (mitogenome). The mtDNAs were clustered into 61 named clades of haplogroup H and did not reveal phylogeographic trends within Italy. Rapid individualization approaches for investigative purposes are limited to the most frequent H clades of the dataset, viz. H1, H3, and H7.

Identifiants

DOI: 10.3390/ijms23126725 PMID: 35743173 PMC: PMC9223851
pubmed: 35743173
pii: ijms23126725
doi: 10.3390/ijms23126725
pmc: PMC9223851
pii:
doi:

Substances chimiques

DNA, Mitochondrial 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Italian Ministry of Education, University and Research (MIUR)
ID : PRIN2017 2017CWHLHY
Organisme : Department of Biology and Biotechnology "L. Spallanzani" University of Pavia
ID : Dipartimenti di Eccellenza Program (2018-2022)
Organisme : Intramural funding program of the Medical University of Innsbruck for young scientists MUISTART
ID : 2013042025
Organisme : Theodor Körner-Fonds zur Förderung von Wissenschaft und Kunst
Organisme : D. Swarovski Förderungsfonds
ID : DSF 2015-1-1
Organisme : Tiroler Wissenschaftsfonds (TWF)
ID : UNI-404/1998
Organisme : Leverhulme Trust

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Auteurs

Martin Bodner (M)

Institute of Legal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
ORCID: 0000-0002-3870-9862

Christina Amory (C)

Institute of Legal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Anna Olivieri (A)

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
ORCID: 0000-0002-3941-8098

Francesca Gandini (F)

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
Department of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

Irene Cardinali (I)

Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
ORCID: 0000-0003-0632-9993

Hovirag Lancioni (H)

Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
ORCID: 0000-0001-5514-1853

Gabriela Huber (G)

Institute of Legal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Catarina Xavier (C)

Institute of Legal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
ORCID: 0000-0003-3522-1631

Maria Pala (M)

Department of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

Alessandro Fichera (A)

Department of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

Lisa Schnaller (L)

Institute of Legal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Mario Gysi (M)

Zurich Institute of Forensic Medicine, University of Zurich, 8057 Zurich, Switzerland.
ORCID: 0000-0002-4649-534X

Stefania Sarno (S)

Laboratory of Molecular Anthropology, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy.

Davide Pettener (D)

Laboratory of Molecular Anthropology, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy.

Donata Luiselli (D)

Laboratory of Ancient DNA, Department of Cultural Heritage, University of Bologna, 48121 Ravenna, Italy.
ORCID: 0000-0003-2105-2478

Martin B Richards (MB)

Department of Biological and Geographical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.
ORCID: 0000-0003-3118-0967

Ornella Semino (O)

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
ORCID: 0000-0002-9675-9403

Alessandro Achilli (A)

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.
ORCID: 0000-0001-6871-3451

Antonio Torroni (A)

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.

Walther Parson (W)

Institute of Legal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Forensic Science Program, The Pennsylvania State University, University Park, PA 16801, USA.
ORCID: 0000-0002-5692-2392

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Helena's Many Daughters: More Mitogenome...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génétique des populations › Helena's Many Daughters: More Mitogenome...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome mitochondrial › Helena's Many Daughters: More Mitogenome...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Haplotypes › Helena's Many Daughters: More Mitogenome...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Caractéristiques familiales › Structure familiale › Famille nucléaire › Helena's Many Daughters: More Mitogenome...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Helena's Many Daughters: More Mitogenome...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Helena's Many Daughters: More Mitogenome...