High ligand efficiency quinazoline compounds as novel A

Adenosine A2 Receptor Antagonists / chemistry Ligands Molecular Docking Simulation Purinergic P1 Receptor Antagonists / pharmacology Quinazolines / pharmacology Receptor, Adenosine A2A / chemistry Structure-Activity Relationship
A(2A) adenosine Receptor Alzheimer Crystallography Parkinson Quinazoline

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Nov 2022
Historique:
received: 12 01 2022
revised: 17 07 2022
accepted: 18 07 2022
pubmed: 8 8 2022
medline: 2 9 2022
entrez: 7 8 2022
Statut: ppublish

Résumé

The past fifty years have been marked by the surge of neurodegenerative diseases. Unfortunately, current treatments are only symptomatic. Hence, the search for new and innovative therapeutic targets for curative treatments becomes a major challenge. Among these targets, the adenosine A

Identifiants

DOI: 10.1016/j.ejmech.2022.114620 PMID: 35933788
pubmed: 35933788
pii: S0223-5234(22)00522-0
doi: 10.1016/j.ejmech.2022.114620
pii:
doi:

Substances chimiques

Adenosine A2 Receptor Antagonists 0
Ligands 0
Purinergic P1 Receptor Antagonists 0
Quinazolines 0
Receptor, Adenosine A2A 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114620

Informations de copyright

Copyright © 2022 Elsevier Masson SAS. All rights reserved.

Auteurs

Raphaël Bolteau (R)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Romain Duroux (R)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Amélie Laversin (A)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Brandon Vreulz (B)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Anna Shiriaeva (A)

Department of Chemistry, University of Southern California, Los Angeles, CA, USA.

Benjamin Stauch (B)

Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern Califorinia, Los Angeles, CA, USA; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.

Gye Won Han (GW)

Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern Califorinia, Los Angeles, CA, USA; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.

Vadim Cherezov (V)

Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern Califorinia, Los Angeles, CA, USA; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.

Nicolas Renault (N)

Univ. Lille, Inserm, U995 - LIRIC - Lille Inflammation Research International Center, ICPAL, 3 rue du Professeur Laguesse, BP-83, F-59006, Lille, France.

Amélie Barczyk (A)

Univ. Lille, Inserm, U995 - LIRIC - Lille Inflammation Research International Center, ICPAL, 3 rue du Professeur Laguesse, BP-83, F-59006, Lille, France.

Séverine Ravez (S)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Mathilde Coevoet (M)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Patricia Melnyk (P)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

Maxime Liberelle (M)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France. Electronic address: maxime.liberelle@univ-lille.fr.

Saïd Yous (S)

Univ. Lille, Inserm, CHU Lille, U1172, LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P1 › Antagonistes des récepteurs A2 à l'adénosine › High ligand efficiency quinazoline compounds as novel A
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › High ligand efficiency quinazoline compounds as novel A
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › High ligand efficiency quinazoline compounds as novel A
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P1 › High ligand efficiency quinazoline compounds as novel A
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › High ligand efficiency quinazoline compounds as novel A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteurs A2 à l'adénosine › Récepteur A2A à l'adénosine › High ligand efficiency quinazoline compounds as novel A
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › High ligand efficiency quinazoline compounds as novel A