Engineering microbial cell viability for enhancing chemical production by second codon engineering.

Cell Survival Codon / genetics Escherichia coli / genetics Metabolic Engineering / methods Reactive Oxygen Species Saccharomyces cerevisiae / genetics
Engineering second codon Microbial cell factories Microbial cell viability ROS

Journal

Metabolic engineering
ISSN: 1096-7184
Titre abrégé: Metab Eng
Pays: Belgium
ID NLM: 9815657

Informations de publication

Date de publication:
09 2022
Historique:
received: 26 10 2021
revised: 29 06 2022
accepted: 12 08 2022
pubmed: 21 8 2022
medline: 14 9 2022
entrez: 20 8 2022
Statut: ppublish

Résumé

Microbial cell factories offer a promising strategy for the sustainable production of industrial chemicals from renewable biomass feedstock. However, their performance is often limited by poor microbial cell viability (MCV). Here, MCV was engineered to enhance chemical production by optimizing the regulation of lifespan-specific genes to reduce the accumulation of reactive oxygen species (ROS). In Escherichia coli, MCV was improved by reducing ROS accumulation using second codon engineering to regulate hypoxia-inducible transcription factor (arcA), resulting in lysine production up to 213 g L

Identifiants

DOI: 10.1016/j.ymben.2022.08.008 PMID: 35987432
pubmed: 35987432
pii: S1096-7176(22)00103-3
doi: 10.1016/j.ymben.2022.08.008
pii:
doi:

Substances chimiques

Codon 0
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

235-246

Informations de copyright

Copyright © 2022 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that there are no competing interests.

Auteurs

Liang Guo (L)

Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.

Mengya Qi (M)

Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.

Cong Gao (C)

Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.

Chao Ye (C)

School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, 210023, China.

Guipeng Hu (G)

School of Pharmaceutical Science, Jiangnan University, Wuxi, 214122, China.

Wei Song (W)

School of Pharmaceutical Science, Jiangnan University, Wuxi, 214122, China.

Jing Wu (J)

School of Pharmaceutical Science, Jiangnan University, Wuxi, 214122, China.

Liming Liu (L)

Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.

Xiulai Chen (X)

Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China. Electronic address: xlchen@jiangnan.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Engineering microbial cell viability for...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Codon › Engineering microbial cell viability for...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Engineering microbial cell viability for...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Engineering microbial cell viability for...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Engineering microbial cell viability for...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Engineering microbial cell viability for...