The genus Serratia revisited by genomics.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 09 2022
03 09 2022
Historique:
received:
01
01
2022
accepted:
24
08
2022
entrez:
3
9
2022
pubmed:
4
9
2022
medline:
9
9
2022
Statut:
epublish
Résumé
The genus Serratia has been studied for over a century and includes clinically-important and diverse environmental members. Despite this, there is a paucity of genomic information across the genus and a robust whole genome-based phylogenetic framework is lacking. Here, we have assembled and analysed a representative set of 664 genomes from across the genus, including 215 historic isolates originally used in defining the genus. Phylogenomic analysis of the genus reveals a clearly-defined population structure which displays deep divisions and aligns with ecological niche, as well as striking congruence between historical biochemical phenotyping data and contemporary genomics data. We highlight the genomic, phenotypic and plasmid diversity of Serratia, and provide evidence of different patterns of gene flow across the genus. Our work provides a framework for understanding the emergence of clinical and other lineages of Serratia.
Identifiants
pubmed: 36057639
doi: 10.1038/s41467-022-32929-2
pii: 10.1038/s41467-022-32929-2
pmc: PMC9440931
doi:
Banques de données
figshare
['10.6084/m9.figshare.18051824']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5195Subventions
Organisme : Wellcome Trust
ID : 220321
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR200639
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104556
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 109118
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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