The Combined Escherichia coli Nissle 1917 and Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model.
Animals
Humans
Infant
Aminobenzoates
Biliverdine
/ metabolism
Cholesterol
Coenzyme A
/ metabolism
Coproporphyrinogens
Cytidine
/ metabolism
Diarrhea
Escherichia coli
/ metabolism
Escherichia coli Infections
Fecal Microbiota Transplantation
Germ-Free Life
Inosine
/ metabolism
Lipids
Malnutrition
/ therapy
Metabolome
Microbiota
Nucleotides
/ metabolism
Phenylalanine
/ metabolism
Rotavirus
Rotavirus Infections
Sulfates
Swine
Tryptophan
/ pharmacology
Urobilinogen
/ metabolism
Xanthines
Escherichia coli Nissle 1917
human rotavirus infection
lipidomics
malnutrition
metabolomics
neonatal gnotobiotic pigs
tryptophan
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
26 Oct 2022
26 Oct 2022
Historique:
pubmed:
9
9
2022
medline:
29
10
2022
entrez:
8
9
2022
Statut:
ppublish
Résumé
Human rotavirus (HRV) is a major cause of childhood diarrhea in developing countries where widespread malnutrition contributes to the decreased oral vaccine efficacy and increased prevalence of other enteric infections, which are major concerns for global health. Neonatal gnotobiotic (Gn) piglets closely resemble human infants in their anatomy, physiology, and outbred status, providing a unique model to investigate malnutrition, supplementations, and HRV infection. To understand the molecular signatures associated with immune enhancement and reduced diarrheal severity by Escherichia coli Nissle 1917 (EcN) and tryptophan (TRP), immunological responses and global nontargeted metabolomics and lipidomics approaches were investigated on the plasma and fecal contents of malnourished pigs transplanted with human infant fecal microbiota and infected with virulent (Vir) HRV. Overall, EcN + TRP combined (rather than individual supplement action) promoted greater and balanced immunoregulatory/immunostimulatory responses associated with greater protection against HRV infection and disease in malnourished humanized piglets. Moreover, EcN + TRP treatment upregulated the production of several metabolites with immunoregulatory/immunostimulatory properties: amino acids (
Identifiants
pubmed: 36073800
doi: 10.1128/msphere.00270-22
pmc: PMC9599269
doi:
Substances chimiques
Aminobenzoates
0
Biliverdine
O9MIA842K9
Cholesterol
97C5T2UQ7J
Coenzyme A
SAA04E81UX
Coproporphyrinogens
0
Cytidine
5CSZ8459RP
Inosine
5A614L51CT
Lipids
0
Nucleotides
0
Phenylalanine
47E5O17Y3R
Sulfates
0
Tryptophan
8DUH1N11BX
Urobilinogen
14684-37-8
Xanthines
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0027022Subventions
Organisme : NICHD NIH HHS
ID : R01 HD095881
Pays : United States
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