Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in
Aspergillus fumigatus
CRISPR
GWA
caspofungin
echinocandin
genomics
mycology
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
26 10 2022
26 10 2022
Historique:
pubmed:
13
9
2022
medline:
29
10
2022
entrez:
12
9
2022
Statut:
ppublish
Résumé
Aspergillus fumigatus is a deadly opportunistic fungal pathogen responsible for ~100,000 annual deaths. Azoles are the first line antifungal agent used against A. fumigatus, but azole resistance has rapidly evolved making treatment challenging. Caspofungin is an important second-line therapy against invasive pulmonary aspergillosis, a severe A. fumigatus infection. Caspofungin functions by inhibiting β-1,3-glucan synthesis, a primary and essential component of the fungal cell wall. A phenomenon termed the caspofungin paradoxical effect (CPE) has been observed in several fungal species where at higher concentrations of caspofungin, chitin replaces β-1,3-glucan, morphology returns to normal, and growth rate increases. CPE appears to occur
Identifiants
pubmed: 36094204
doi: 10.1128/spectrum.00519-22
pmc: PMC9603777
doi:
Substances chimiques
Caspofungin
F0XDI6ZL63
Antifungal Agents
0
Echinocandins
0
Fungal Proteins
0
Azoles
0
Chitin
1398-61-4
Phosphoric Monoester Hydrolases
EC 3.1.3.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0051922Subventions
Organisme : NIAID NIH HHS
ID : R01 AI158442
Pays : United States
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