Dissociative episode and panic attacks triggered by pitolisant in a narcoleptic patient.
Journal
International clinical psychopharmacology
ISSN: 1473-5857
Titre abrégé: Int Clin Psychopharmacol
Pays: England
ID NLM: 8609061
Informations de publication
Date de publication:
01 03 2023
01 03 2023
Historique:
pubmed:
28
9
2022
medline:
3
2
2023
entrez:
27
9
2022
Statut:
ppublish
Résumé
Pitolisant is a histamine 3-receptor antagonist/inverse agonist effective and safe for the treatment of excessive daytime sleepiness and cataplexy in narcolepsy. We report a 19-year-old woman affected by narcolepsy type 1 who presented panic attacks and dissociative symptoms induced by pitolisant. The patient medical history was unremarkable except that for familiarity for anxiety disorder and chronic insomnia. Moreover, a detailed psychometric evaluation revealed a profile of low resilience, a severe grade of depression, an anxiety trait and a propension to dissociative symptoms. Our report suggests that caution should be used in patients with predisposing factors to psychiatric disorders, especially during the first period of treatment with pitolisant. In consideration of the high prevalence of psychiatric comorbidities in narcolepsy, it seems worth to carefully investigate psychiatric background of narcoleptic patients.
Identifiants
pubmed: 36165509
doi: 10.1097/YIC.0000000000000430
pii: 00004850-202303000-00008
doi:
Substances chimiques
pitolisant
4BC83L4PIY
Histamine Agonists
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114-116Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
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