Direct In Vitro Comparison of the Anti-Leishmanial Activity of Different Olive Oil Total Polyphenolic Fractions and Assessment of Their Combined Effects with Miltefosine.
combination therapy
intracellular amastigotes
isobologram
leishmaniasis
natural products
promastigotes
total phenolic fraction
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Sep 2022
21 Sep 2022
Historique:
received:
11
08
2022
revised:
09
09
2022
accepted:
17
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
The bioactive compounds present in the edible products of the olive tree have been extensively studied and their favorable effects on various disease risk factors have been demonstrated. The aim of this study was to perform a comparative analysis of the anti-leishmanial effects of total phenolic fractions (TPFs) derived from extra virgin olive oil with different phenolic contents and diverse quantitative patterns. Moreover, the present study investigated their association with miltefosine, a standard anti-leishmanial drug, against both extracellular promastigotes and intracellular amastigotes of a viscerotropic and a dermotropic
Identifiants
pubmed: 36234713
pii: molecules27196176
doi: 10.3390/molecules27196176
pmc: PMC9571123
pii:
doi:
Substances chimiques
Aldehydes
0
Antiprotozoal Agents
0
Cyclopentane Monoterpenes
0
Iridoids
0
Olive Oil
0
Phenols
0
Reactive Oxygen Species
0
oleacein
0
Phosphorylcholine
107-73-3
miltefosine
53EY29W7EC
oleocanthal
AC7QO6038O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund of EE and the Greek National Funds
ID : MIS 5134622
Organisme : Greek State and the European Regional Development Fund
ID : MIS5028091
Organisme : Nostos Foundation Trust Fund
ID : PhD Fellowship
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