Nociceptor neurons affect cancer immunosurveillance.

Animals Mice Calcitonin Gene-Related Peptide / metabolism CD8-Positive T-Lymphocytes / immunology Melanoma / immunology Nociceptors / physiology Sensory Receptor Cells / metabolism Neurites / metabolism Lymphocytes, Tumor-Infiltrating / immunology Survival Rate Melanoma, Experimental / immunology Genes, RAG-1 / genetics Humans Biopsy Prognosis

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Nov 2022
Historique:
received: 09 06 2021
accepted: 21 09 2022
pubmed: 4 11 2022
medline: 15 11 2022
entrez: 3 11 2022
Statut: ppublish

Résumé

Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems

Identifiants

DOI: 10.1038/s41586-022-05374-w PMID: 36323780 PMC: PMC9646485
pubmed: 36323780
doi: 10.1038/s41586-022-05374-w
pii: 10.1038/s41586-022-05374-w
pmc: PMC9646485
doi:

Substances chimiques

Calcitonin Gene-Related Peptide JHB2QIZ69Z
Ramp1 protein, mouse 0
TRPV1 protein, mouse 0
RAMP1 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

405-412

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS105076
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103620
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103548
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Mohammad Balood (M)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, Quebec, Canada.

Maryam Ahmadi (M)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.

Tuany Eichwald (T)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

Ali Ahmadi (A)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.

Abdelilah Majdoubi (A)

Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Quebec, Canada.

Karine Roversi (K)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.

Katiane Roversi (K)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.

Christopher T Lucido (CT)

Cancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.

Anthony C Restaino (AC)

Cancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.
ORCID: 0000-0002-5562-2670

Siyi Huang (S)

Cygnal Therapeutics, Cambridge, MA, USA.

Lexiang Ji (L)

Cygnal Therapeutics, Cambridge, MA, USA.

Kai-Chih Huang (KC)

Cygnal Therapeutics, Cambridge, MA, USA.

Elise Semerena (E)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.
ORCID: 0000-0002-8954-6274

Sini C Thomas (SC)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.

Alexandro E Trevino (AE)

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

Hannah Merrison (H)

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

Alexandre Parrin (A)

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

Benjamin Doyle (B)

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

Daniel W Vermeer (DW)

Cancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.

William C Spanos (WC)

Cancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.
ORCID: 0000-0002-7975-1151

Caitlin S Williamson (CS)

Cancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.

Corey R Seehus (CR)

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

Simmie L Foster (SL)

Depression Clinical Research Program, Massachusetts General Hospital, Boston, MA, USA.

Hongyue Dai (H)

Cygnal Therapeutics, Cambridge, MA, USA.

Chengyi J Shu (CJ)

Cygnal Therapeutics, Cambridge, MA, USA.

Manu Rangachari (M)

Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec, Quebec, Canada.

Jacques Thibodeau (J)

Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Quebec, Canada.

Sonia V Del Rincon (S)

Department of Oncology, McGill University, Montréal, Quebec, Canada.

Ronny Drapkin (R)

Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-6912-6977

Moutih Rafei (M)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada.

Nader Ghasemlou (N)

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
ORCID: 0000-0002-1696-7342

Paola D Vermeer (PD)

Cancer Biology and Immunotherapies, Sanford Research, Sioux Falls, SD, USA.
ORCID: 0000-0003-2370-8223

Clifford J Woolf (CJ)

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-6636-3897

Sebastien Talbot (S)

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, Quebec, Canada. sebastien.talbot@queensu.ca.
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. sebastien.talbot@queensu.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Nociceptor neurons affect cancer immunosurveillance.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Nociceptor neurons affect cancer immunosurveillance.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide relié au gène de la calcitonine › Nociceptor neurons affect cancer immunosurveillance.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Nociceptor neurons affect cancer immunosurveillance.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Nociceptor neurons affect cancer immunosurveillance.
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Nocicepteurs › Nociceptor neurons affect cancer immunosurveillance.
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Nociceptor neurons affect cancer immunosurveillance.
questionsmedicales.fr › Cellules › Neurones › Neurites › Nociceptor neurons affect cancer immunosurveillance.
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