A journey across dopamine Metabolism: A rotational study of DOPAC.
Conformational panorama
High-resolution spectroscopy
Neurotransmitters
Rotational spectroscopy
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
05 Apr 2023
05 Apr 2023
Historique:
received:
05
11
2022
revised:
27
12
2022
accepted:
28
12
2022
pubmed:
7
1
2023
medline:
15
2
2023
entrez:
6
1
2023
Statut:
ppublish
Résumé
DOPAC, a relevant scaffold in dopamine metabolism, was probed in the gas phase and interrogated by high-resolution rotational spectroscopy. Herein, three distinct conformers were isolated in a supersonic jet and identified for the first time through an examination of the trend of the rotational constants and the dipole moment selection rules. Additionally, we examined the plausible relaxation pathways of the low-energy conformers of DOPAC, which helped us to claim the indirect detection of two additional conformers, providing conclusive experimental evidence of the flexible nature of this biomolecule. The current investigation sheds some light on the differences between jet-cooled rotational experiments and matrix-isolation infrared spectroscopy.
Identifiants
pubmed: 36608514
pii: S1386-1425(22)01451-2
doi: 10.1016/j.saa.2022.122303
pii:
doi:
Substances chimiques
3,4-Dihydroxyphenylacetic Acid
102-32-9
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122303Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.