Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits.

Dorsal Raphe Nucleus / metabolism Serotonergic Neurons / metabolism Serotonin / metabolism Hypothalamus / metabolism Hormones
5HT Dorsal raphe Feeding Satiety Serotonin

Journal

Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730

Informations de publication

Date de publication:
03 2023
Historique:
received: 16 06 2022
revised: 04 12 2022
accepted: 13 01 2023
pubmed: 23 1 2023
medline: 4 3 2023
entrez: 22 1 2023
Statut: ppublish

Résumé

Serotonin (5HT) is a well-known anorexigenic molecule, and 5HT neurons of dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the downstream circuitry is poorly understood. Here we explored major projections of DRN We used optogenetics to selectively activate DRN We found that selective activation of DRN These findings define functionally redundant forebrain circuits through which DRN

Identifiants

DOI: 10.1016/j.molmet.2023.101676 PMID: 36682413 PMC: PMC9923194
pubmed: 36682413
pii: S2212-8778(23)00010-8
doi: 10.1016/j.molmet.2023.101676
pmc: PMC9923194
pii:
doi:

Substances chimiques

Serotonin 333DO1RDJY
Hormones 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

101676

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK126740
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier GmbH.. All rights reserved.

Auteurs

Iltan Aklan (I)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Nilufer Sayar-Atasoy (N)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Fei Deng (F)

State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.

Hyojin Kim (H)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Yavuz Yavuz (Y)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Department of Physiology, School of Medicine, Yeditepe University, Istanbul, Turkey.

Jacob Rysted (J)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Connor Laule (C)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Debbie Davis (D)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Yulong Li (Y)

State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.

Deniz Atasoy (D)

Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center (FOEDRC), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: deniz-atasoy@uiowa.edu.

Articles similaires

The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs.

Xinyu Li, Siman Wang, Dianjun Zhang et al.
1.00
Cerebrospinal Fluid Animals Liver Glymphatic System Spinal Cord

Targeting the hypothalamus for modeling age-related DNA methylation and developing OXT-GnRH combinational therapy against Alzheimer's disease-like pathologies in male mouse model.

Salman Sadullah Usmani, Hyun-Gug Jung, Qichao Zhang et al.
1.00
Animals DNA Methylation Hypothalamus Alzheimer Disease Male

Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model.

Timothy D Allerton, James E Stampley, Zhen Li et al.
1.00
Animals Alzheimer Disease Obesity Mitochondria Mice

Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus.

Prashant Tarale, Shaista Chaudhary, Sayani Mukherjee et al.
1.00
Animals Ethanol Rats Exosomes Neurons

Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Noyau dorsal du raphé › Dorsal raphe serotonergic neurons suppress...
questionsmedicales.fr › Cellules › Neurones › Neurones sérotonergiques › Dorsal raphe serotonergic neurons suppress...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Dorsal raphe serotonergic neurons suppress...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Dorsal raphe serotonergic neurons suppress...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Dorsal raphe serotonergic neurons suppress...