The Intertwined Role of 8-oxodG and G4 in Transcription Regulation.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Jan 2023
Historique:
received: 16 12 2022
revised: 11 01 2023
accepted: 14 01 2023
entrez: 11 2 2023
pubmed: 12 2 2023
medline: 15 2 2023
Statut: epublish

Résumé

The guanine base in nucleic acids is, among the other bases, the most susceptible to being converted into 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) when exposed to reactive oxygen species. In double-helix DNA, 8-oxodG can pair with adenine; hence, it may cause a G > T (C > A) mutation; it is frequently referred to as a form of DNA damage and promptly corrected by DNA repair mechanisms. Moreover, 8-oxodG has recently been redefined as an epigenetic factor that impacts transcriptional regulatory elements and other epigenetic modifications. It has been proposed that 8-oxodG exerts epigenetic control through interplay with the G-quadruplex (G4), a non-canonical DNA structure, in transcription regulatory regions. In this review, we focused on the epigenetic roles of 8-oxodG and the G4 and explored their interplay at the genomic level.

Identifiants

pubmed: 36768357
pii: ijms24032031
doi: 10.3390/ijms24032031
pmc: PMC9916577
pii:
doi:

Substances chimiques

8-Hydroxy-2'-Deoxyguanosine 88847-89-6
Deoxyguanosine G9481N71RO
DNA 9007-49-2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Références

Nat Biotechnol. 2015 Aug;33(8):877-81
pubmed: 26192317
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Nucleic Acids Res. 2018 Apr 20;46(7):3270-3283
pubmed: 29554280
Chemistry. 2019 Jan 7;25(2):417-430
pubmed: 30051593
J Am Chem Soc. 2019 Feb 13;141(6):2594-2603
pubmed: 30657306
Oncogene. 2005 Apr 28;24(19):3110-20
pubmed: 15735682
Nucleic Acids Res. 2020 May 7;48(8):4309-4324
pubmed: 32198884
J Am Chem Soc. 2002 Mar 13;124(10):2098-9
pubmed: 11878947
Nat Commun. 2021 Oct 14;12(1):6014
pubmed: 34650044
ACS Cent Sci. 2015 Aug 26;1(5):226-233
pubmed: 26405692
J Am Chem Soc. 2017 Feb 22;139(7):2569-2572
pubmed: 28150947
Nat Commun. 2021 Jun 23;12(1):3885
pubmed: 34162892
Front Chem. 2018 Jul 24;6:281
pubmed: 30137743
Nucleic Acids Res. 2022 Apr 8;50(6):3394-3412
pubmed: 35286386
DNA Repair (Amst). 2010 Jun 4;9(6):604-16
pubmed: 20399712
Sci Rep. 2021 Feb 10;11(1):3490
pubmed: 33568707
Nucleic Acids Res. 2015 Apr 30;43(8):4028-38
pubmed: 25813046
Invest New Drugs. 2013 Jun;31(3):714-23
pubmed: 23054206
DNA Repair (Amst). 2021 Jan;97:103027
pubmed: 33285475
Nucleic Acids Res. 2014 Jul;42(13):8379-88
pubmed: 25013182
Biochemistry. 2018 May 22;57(20):2958-2970
pubmed: 29718661
Chem Res Toxicol. 2019 Mar 18;32(3):437-446
pubmed: 30604962
J Am Chem Soc. 2019 Jul 17;141(28):11036-11049
pubmed: 31241930
Biochemistry. 2018 Feb 13;57(6):991-1002
pubmed: 29320161
Biochim Biophys Acta. 2016 Apr;1859(4):663-74
pubmed: 26855080
Molecules. 2020 Aug 13;25(16):
pubmed: 32823549
Redox Biol. 2020 Jan;29:101398
pubmed: 31926624
Cell Rep. 2020 Dec 22;33(12):108546
pubmed: 33357438
Nucleic Acids Res. 2019 Jan 10;47(1):221-236
pubmed: 30462294
Cancer Res. 2005 Feb 15;65(4):1489-96
pubmed: 15735037
Nucleic Acids Res. 2022 Feb 22;50(3):e13
pubmed: 34792172
Trends Chem. 2020 Feb;2(2):123-136
pubmed: 32923997
Biomolecules. 2020 Oct 26;10(11):
pubmed: 33114607
Biochemistry. 2019 Jan 29;58(4):245-249
pubmed: 30350580
Int J Mol Sci. 2021 Nov 22;22(22):
pubmed: 34830478
Trends Mol Med. 2020 Sep;26(9):848-861
pubmed: 32467069
Biochemistry. 2020 Jul 21;59(28):2627-2639
pubmed: 32578995
Nucleic Acids Res. 2022 Jan 7;50(D1):D150-D160
pubmed: 34718746
Nature. 1988 Jul 28;334(6180):364-6
pubmed: 3393228
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22183-22192
pubmed: 32826329
Sci Rep. 2017 Mar 07;7:43297
pubmed: 28266569
Nucleic Acids Res. 2012 Feb;40(4):1499-508
pubmed: 22021377
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11409-11420
pubmed: 32404420
Nucleic Acids Res. 2022 Apr 8;50(6):3292-3306
pubmed: 35234932
Science. 2008 Jan 11;319(5860):202-6
pubmed: 18187655
Oncogene. 2010 Jun 24;29(25):3691-702
pubmed: 20418916
Nucleic Acids Res. 2020 Sep 18;48(16):8943-8958
pubmed: 32697292
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11593-8
pubmed: 12195017
Free Radic Biol Med. 2012 Jul 1;53(1):51-9
pubmed: 22583700
Nucleic Acids Res. 2006;34(19):5402-15
pubmed: 17012276
J Am Chem Soc. 2008 Nov 26;130(47):15758-9
pubmed: 18975896
Cell Cycle. 2010 Aug 1;9(15):3002-4
pubmed: 20714214
Epigenetics. 2019 Sep;14(9):894-911
pubmed: 31177910
Nat Genet. 2016 Oct;48(10):1267-72
pubmed: 27618450
Front Cell Dev Biol. 2020 Sep 09;8:564601
pubmed: 33015058
J Am Chem Soc. 2018 Feb 14;140(6):2105-2114
pubmed: 29376367
Essays Biochem. 2020 Oct 26;64(5):831-843
pubmed: 32648895
EMBO J. 2014 Nov 3;33(21):2507-20
pubmed: 25190518
Nucleic Acids Res. 2021 Jan 11;49(1):416-431
pubmed: 33313902
Nat Rev Mol Cell Biol. 2020 Aug;21(8):459-474
pubmed: 32313204
J Am Chem Soc. 2020 Jan 22;142(3):1115-1136
pubmed: 31880930
Nucleic Acids Res. 2018 Jan 25;46(2):661-676
pubmed: 29165690
J Med Chem. 2013 Apr 11;56(7):2959-74
pubmed: 23514618
Chem Res Toxicol. 2013 Apr 15;26(4):593-607
pubmed: 23438298
Mutat Res. 2004 Sep;567(1):1-61
pubmed: 15341901
Front Cell Dev Biol. 2021 Nov 19;9:758402
pubmed: 34869348
Molecules. 2019 Sep 22;24(19):
pubmed: 31546714
Cell Biosci. 2020 Mar 26;10:47
pubmed: 32257105
FEBS J. 2010 Sep;277(17):3459-69
pubmed: 20670278
Nucleic Acids Res. 2021 Dec 2;49(21):12252-12267
pubmed: 34788860
Biochim Biophys Acta. 2013 Oct;1829(10):981-6
pubmed: 23684752
Genes (Basel). 2019 Jan 29;10(2):
pubmed: 30700033
Nucleic Acids Res. 2020 Dec 2;48(21):11942-11957
pubmed: 33137181
FEBS J. 2010 Sep;277(17):3452-8
pubmed: 20670279
J Biol Chem. 2016 Dec 2;291(49):25553-25566
pubmed: 27756845
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2604-2609
pubmed: 28143930
Oncotarget. 2017 Aug 09;8(45):79864-79875
pubmed: 29108368
ACS Chem Biol. 2018 Sep 21;13(9):2577-2584
pubmed: 30063821
Nucleic Acids Res. 2021 Sep 7;49(15):8419-8431
pubmed: 34255847
Nucleic Acids Res. 2020 Nov 18;48(20):11706-11720
pubmed: 33045726
Cancer Res. 1999 Feb 1;59(3):639-44
pubmed: 9973212
Exp Mol Med. 2022 Oct;54(10):1626-1642
pubmed: 36266447
Mol Pharmacol. 2001 Nov;60(5):981-8
pubmed: 11641426
Genome Biol. 2018 Dec 7;19(1):215
pubmed: 30526646
Cell Mol Life Sci. 2018 Oct;75(20):3741-3750
pubmed: 30043138
Mol Cancer. 2022 Sep 17;21(1):180
pubmed: 36114513
PLoS One. 2013;8(2):e56592
pubmed: 23451058
ACS Chem Biol. 2016 Jan 15;11(1):139-48
pubmed: 26462961
Mol Cancer. 2021 Feb 25;20(1):40
pubmed: 33632214
DNA Repair (Amst). 2017 Aug;56:75-83
pubmed: 28629775
NAR Cancer. 2021 Sep 16;3(3):zcab038
pubmed: 34541539
J Am Chem Soc. 2018 Aug 8;140(31):9783-9787
pubmed: 29944356
Nucleic Acids Res. 2006 May 10;34(9):2536-49
pubmed: 16687659
Nucleic Acids Res. 2019 May 7;47(8):3862-3874
pubmed: 30892612
FASEB J. 2003 Jul;17(10):1195-214
pubmed: 12832285

Auteurs

Francesca Gorini (F)

Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.

Susanna Ambrosio (S)

Department of Biology, University of Naples Federico II, 80138 Naples, Italy.

Luigi Lania (L)

Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.

Barbara Majello (B)

Department of Biology, University of Naples Federico II, 80138 Naples, Italy.

Stefano Amente (S)

Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.

Articles similaires

DNA Methylation Humans DNA Animals Machine Learning
DNA Glycosylases Nucleosomes Humans 8-Hydroxy-2'-Deoxyguanosine DNA Repair
Humans Induced Pluripotent Stem Cells Schizophrenia Neural Stem Cells DNA Damage
Alleles Benchmarking Transcription Factors Humans Chromatin Immunoprecipitation Sequencing

Classifications MeSH