Engineered Synthetic STxB for Enhanced Cytosolic Delivery.
endosomal escape
engineered protein
hydrophobic moieties
organic synthesis
synthetic carrier
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
30 04 2023
30 04 2023
Historique:
received:
13
01
2023
revised:
12
04
2023
accepted:
24
04
2023
medline:
15
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
epublish
Résumé
Many molecular targets for cancer therapy are located in the cytosol. Therapeutic macromolecules are generally not able to spontaneously translocate across membranes to reach these cytosolic targets. Therefore a strong need exists for tools that enhance cytosolic delivery. Shiga toxin B-subunit (STxB) is used to deliver therapeutic principles to disease-relevant cells that express its receptor, the glycolipid Gb3. Based on its naturally existing membrane translocation capacity, STxB delivers antigens to the cytosol of Gb3-positive dendritic cells, leading to the induction of CD8
Identifiants
pubmed: 37174690
pii: cells12091291
doi: 10.3390/cells12091291
pmc: PMC10177378
pii:
doi:
Substances chimiques
Shiga Toxin
75757-64-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
J Immunol. 2007 Sep 1;179(5):3371-9
pubmed: 17709554
Biochemistry. 2012 Jul 10;51(27):5531-9
pubmed: 22712882
ACS Chem Biol. 2019 Apr 19;14(4):599-602
pubmed: 30830748
Nat Commun. 2017 May 24;8:15221
pubmed: 28537262
J Control Release. 2009 Sep 1;138(2):128-33
pubmed: 19465072
Biochimie. 2006 Sep;88(9):1199-207
pubmed: 16697101
Nat Rev Microbiol. 2010 Feb;8(2):105-16
pubmed: 20023663
J Control Release. 2011 May 10;151(3):220-8
pubmed: 21078351
J Am Chem Soc. 2017 Oct 18;139(41):14396-14398
pubmed: 28976737
Oncotarget. 2015 Sep 29;6(29):27832-46
pubmed: 26337837
Semin Immunopathol. 2019 Jan;41(1):69-85
pubmed: 29978248
J Immunother Cancer. 2021 Mar;9(3):
pubmed: 33692218
Cancer Res. 2013 Jan 1;73(1):128-38
pubmed: 23135914
Toxins (Basel). 2022 Mar 10;14(3):
pubmed: 35324699
Angew Chem Int Ed Engl. 2021 Jun 25;60(27):14824-14830
pubmed: 33904231
Eur Phys J E Soft Matter. 2008 May-Jun;26(1-2):205-16
pubmed: 18480963
Blood. 2011 Nov 3;118(18):4853-62
pubmed: 21908423
J Cell Sci. 2015 Jul 1;128(13):2373-87
pubmed: 25977475
Int Immunol. 2003 Oct;15(10):1161-71
pubmed: 13679386
Nat Biomed Eng. 2021 Sep;5(9):951-967
pubmed: 33795852
Nat Struct Biol. 2001 Aug;8(8):715-20
pubmed: 11473264
Biochemistry. 2003 Aug 12;42(31):9498-506
pubmed: 12899637
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
J Immunol. 2000 Sep 15;165(6):3301-8
pubmed: 10975847
Sci Transl Med. 2013 Feb 13;5(172):172ra20
pubmed: 23408053
Cancer Res. 2006 Jul 15;66(14):7230-6
pubmed: 16849571
Biochim Biophys Acta. 2007 Mar;1768(3):628-36
pubmed: 17258170
J Exp Med. 1986 Jun 1;163(6):1391-404
pubmed: 3519828
Sci Rep. 2016 Sep 08;6:32301
pubmed: 27604151
Bioconjug Chem. 2019 Feb 20;30(2):273-283
pubmed: 30525488
Mol Imaging. 2008 Nov-Dec;7(6):239-47
pubmed: 19123994