Anti-inflammatory and α-glucosidase inhibitory constituents from Dendrobium nobile Lindl.

Molecular Structure alpha-Glucosidases Dendrobium / chemistry Molecular Docking Simulation Kinetics Glycoside Hydrolase Inhibitors / pharmacology
Anti-inflammatory activity Bibenzyl Dendrobium nobile Molecular docking α-Glucosidase inhibition

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 03 05 2023
revised: 13 06 2023
accepted: 14 06 2023
medline: 21 8 2023
pubmed: 19 6 2023
entrez: 18 6 2023
Statut: ppublish

Résumé

Four new compounds ((±)-1-3), including one pair of enantiomers ((±)-1), along with 11 known bibenzyls (4-14) were isolated from Dendrobium nobile. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR as well as HRESIMS. The configurations of (±)-1 were established via the electronic circular dichroism (ECD) calculations. Compounds (+)-1 and 13 displayed pronounced α-glucosidase inhibitory activities with IC

Identifiants

DOI: 10.1016/j.fitote.2023.105582 PMID: 37331407
pubmed: 37331407
pii: S0367-326X(23)00157-0
doi: 10.1016/j.fitote.2023.105582
pii:
doi:

Substances chimiques

alpha-Glucosidases EC 3.2.1.20
Glycoside Hydrolase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105582

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no competing financial interest that could have appeared to influence the work reported in this paper.

Auteurs

Dong-Sheng Guo (DS)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China.

Xue Cao (X)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China.

Hui-Qin Chen (HQ)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China.

Yan-Mei Wei (YM)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China.

Hao Wang (H)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China.

Cai-Hong Cai (CH)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China.

Hao-Fu Dai (HF)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China. Electronic address: daihaofu@itbb.org.cn.

Li Yang (L)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China. Electronic address: yangli@itbb.org.cn.

Wen-Li Mei (WL)

Key Laboratory of Natural Products Research and Development of Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan 571101, China; Key Laboratory of Conservation and Utilization of Tropical Agro-bioresources of Hainan Province, Hainan Academy of Tropical Agricultural Resources, Haikou, Hainan 571101, China. Electronic address: meiwenli@itbb.org.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Anti-inflammatory and α-glucosidase inhibitory...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Anti-inflammatory and α-glucosidase inhibitory...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Orchidaceae › Dendrobium › Anti-inflammatory and α-glucosidase inhibitory...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Anti-inflammatory and α-glucosidase inhibitory...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Anti-inflammatory and α-glucosidase inhibitory...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Anti-inflammatory and α-glucosidase inhibitory...