Atomic Insight on Inhibition of Fibrillization of Dipeptides by Replacement of Phenylalanine with Tryptophan.

Tryptophan Phenylalanine / chemistry Protein Conformation Dipeptides Peptides / chemistry Crystallography, X-Ray Hydrogen Bonding

Journal

Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Titre abrégé: Langmuir
Pays: United States
ID NLM: 9882736

Informations de publication

Date de publication:
11 07 2023
Historique:
medline: 12 7 2023
pubmed: 20 6 2023
entrez: 20 6 2023
Statut: ppublish

Résumé

Tryptophan (Trp) conjugates destabilize amyloid fibrils responsible for amyloidoses. However, the mechanism of such destabilization is obscure. Herein the self-assembly of four synthesized Trp-containing dipeptides Boc-xxx-Trp-OMe (xxx: Val, Leu, Ile, and Phe) has been investigated and compared with the existing report on their Phe congeners. Two among them are the C-terminal tryptophan analogs of Boc-Val-Phe-OMe (VF, Aβ

Identifiants

DOI: 10.1021/acs.langmuir.3c00823 PMID: 37339161
pubmed: 37339161
doi: 10.1021/acs.langmuir.3c00823
doi:

Substances chimiques

Tryptophan 8DUH1N11BX
Phenylalanine 47E5O17Y3R
Dipeptides 0
Peptides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9367-9383

Auteurs

Gobinda Dolai (G)

Department of Chemistry, Laboratory of Peptide and Amyloid Research, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.

Sukesh Shill (S)

Department of Chemistry, Laboratory of Peptide and Amyloid Research, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.

Sayanta Roy (S)

Department of Chemistry, Laboratory of Peptide and Amyloid Research, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.

Bhubaneswar Mandal (B)

Department of Chemistry, Laboratory of Peptide and Amyloid Research, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
ORCID: 0000-0003-3435-5443

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Atomic Insight on Inhibition of Fibrillization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Phénylalanine › Atomic Insight on Inhibition of Fibrillization...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Atomic Insight on Inhibition of Fibrillization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Dipeptides › Atomic Insight on Inhibition of Fibrillization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Atomic Insight on Inhibition of Fibrillization...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Atomic Insight on Inhibition of Fibrillization...
questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Atomic Insight on Inhibition of Fibrillization...