Impact of curcumin on p38 MAPK: therapeutic implications.

Curcumin / pharmacology p38 Mitogen-Activated Protein Kinases / metabolism Mitogen-Activated Protein Kinases / metabolism Signal Transduction NF-kappa B / metabolism Janus Kinases / metabolism MAP Kinase Signaling System
Curcumin Inflammation MAPK Phytochemical p38

Journal

Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 28 03 2023
accepted: 08 06 2023
medline: 26 9 2023
pubmed: 27 7 2023
entrez: 27 7 2023
Statut: ppublish

Résumé

Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including nuclear factor kappa B (NF-KB), reactive oxygen species (ROS), Wingless/Integrated (Wnt), Janus kinase-signal transducer and activator of mitogen-activated protein kinase (MAPK) and transcription (JAK/STAT). P38 belongs to the MAPKs, is known as a stress-activated MAPK and is involved in diverse biological responses. P38 is activated in various signaling cascades. P38 plays a role in inflammation, cell differentiation, proliferation, motility and survival. This cascade can serve as a therapeutic target in many disorders. Extensive evidence confirms that curcumin impacts the P38 MAPK signaling pathway, through which it exerts anti-inflammatory, neuroprotective, and apoptotic effects. Hence, curcumin can positively affect inflammatory disorders and cancers, as well as to increase glucose uptake in cells. This review discusses the pharmacological and therapeutic effects of curcumin as effected through p38 MAPK.

Identifiants

DOI: 10.1007/s10787-023-01265-2 PMID: 37498375
pubmed: 37498375
doi: 10.1007/s10787-023-01265-2
pii: 10.1007/s10787-023-01265-2
doi:

Substances chimiques

Curcumin IT942ZTH98
p38 Mitogen-Activated Protein Kinases EC 2.7.11.24
Mitogen-Activated Protein Kinases EC 2.7.11.24
NF-kappa B 0
Janus Kinases EC 2.7.10.2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2201-2212

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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Auteurs

Hedieh Sadat Shamsnia (HS)

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Mahtab Roustaei (M)

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Danial Ahmadvand (D)

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Alexandra E Butler (AE)

Research Department, Royal College of Surgeons in Ireland Bahrain, Adliya, Bahrain.
ORCID: 0000-0002-5762-3917

Dorsa Amirlou (D)

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Sanam Soltani (S)

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Saeideh Momtaz (S)

Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
Department of Toxicology and Pharmacology, School of Pharmacy, and Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

Tannaz Jamialahmadi (T)

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Amir Hossein Abdolghaffari (AH)

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. amirhosein172@hotmail.com.
GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. amirhosein172@hotmail.com.

Amirhossein Sahebkar (A)

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.
School of Medicine, The University of Western Australia, Perth, Australia. amir_saheb2000@yahoo.com.
Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Impact of curcumin on p38 MAPK: therapeutic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › p38 Mitogen-Activated Protein Kinases › Impact of curcumin on p38 MAPK: therapeutic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Impact of curcumin on p38 MAPK: therapeutic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Impact of curcumin on p38 MAPK: therapeutic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Impact of curcumin on p38 MAPK: therapeutic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Janus kinases › Impact of curcumin on p38 MAPK: therapeutic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Impact of curcumin on p38 MAPK: therapeutic...