Two-Dimensional NMR Spectroscopy of the G Protein-Coupled Receptor A


Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
14 Jul 2023
Historique:
received: 08 06 2023
revised: 07 07 2023
accepted: 08 07 2023
medline: 31 7 2023
pubmed: 29 7 2023
entrez: 29 7 2023
Statut: epublish

Résumé

Eight hundred and twenty-six human G protein-coupled receptors (GPCRs) mediate the actions of two-thirds of the human hormones and neurotransmitters and over one-third of clinically used drugs. Studying the structure and dynamics of human GPCRs in lipid bilayer environments resembling the native cell membrane milieu is of great interest as a basis for understanding structure-function relationships and thus benefits continued drug development. Here, we incorporate the human A

Identifiants

pubmed: 37513291
pii: molecules28145419
doi: 10.3390/molecules28145419
pmc: PMC10383251
pii:
doi:

Substances chimiques

Lipid Bilayers 0
Micelles 0
Tryptophan 8DUH1N11BX
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Natural Science Foundation of China
ID : 31971153
Organisme : National Natural Science Foundation of China
ID : 21904088

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Auteurs

Canyong Guo (C)

iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Lingyun Yang (L)

iHuman Institute, ShanghaiTech University, Shanghai 201210, China.

Zhijun Liu (Z)

National Facility for Protein Science in Shanghai, ZhangJiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.

Dongsheng Liu (D)

iHuman Institute, ShanghaiTech University, Shanghai 201210, China.

Kurt Wüthrich (K)

iHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.
Institute of Molecular Biology and Biophysics, ETH Zürich, Otto-Stern-Weg 5, 8093 Zürich, Switzerland.

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Classifications MeSH