Synthesis, biological evaluation, and molecular modelling of novel quinoxaline-isoxazole hybrid as anti-hyperglycemic.

Molecular Docking Simulation alpha-Glucosidases / metabolism Quinoxalines / pharmacology Glycoside Hydrolase Inhibitors / chemistry alpha-Amylases Molecular Structure Structure-Activity Relationship
Anti-hyperglycemic Isoxazole Molecular modelling Quinoxaline α-amylase α-glucosidase

Journal

Computational biology and chemistry
ISSN: 1476-928X
Titre abrégé: Comput Biol Chem
Pays: England
ID NLM: 101157394

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 09 05 2023
revised: 31 07 2023
accepted: 31 07 2023
medline: 6 9 2023
pubmed: 6 8 2023
entrez: 5 8 2023
Statut: ppublish

Résumé

In our effort to develop potent anti-hyperglycemic compounds with inhibitory activity against α-amylase and α-glucosidase, a series of novel quinoxaline-isoxazole moieties were synthesized. The novel quinoxaline-isoxazole derivatives were assessed in vitro for their anti-hyperglycemic activities on α-amylase and α-glucosidase inhibitions. The results revealed promising IC

Identifiants

DOI: 10.1016/j.compbiolchem.2023.107938 PMID: 37542847
pubmed: 37542847
pii: S1476-9271(23)00129-9
doi: 10.1016/j.compbiolchem.2023.107938
pii:
doi:

Substances chimiques

alpha-Glucosidases EC 3.2.1.20
Quinoxalines 0
Glycoside Hydrolase Inhibitors 0
alpha-Amylases EC 3.2.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

107938

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Lacksany Phongphane (L)

Natural Products and Synthesis Organic Research Laboratory (NPSO), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

Siti Nurshahira Mohd Radzuan (SN)

Natural Products and Synthesis Organic Research Laboratory (NPSO), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

Mohamad Hafizi Abu Bakar (MH)

Bioprocess Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

Mohammad Tasyriq Che Omar (MT)

Biological Section, School of Distance Education, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

Unang Supratman (U)

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, 45363 Jatinangor, Indonesia.

Desi Harneti (D)

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, 45363 Jatinangor, Indonesia.

Habibah A Wahab (H)

School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

Mohamad Nurul Azmi (MN)

Natural Products and Synthesis Organic Research Laboratory (NPSO), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia. Electronic address: mnazmi@usm.my.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis, biological evaluation, and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Synthesis, biological evaluation, and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoxalines › Synthesis, biological evaluation, and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Synthesis, biological evaluation, and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › alpha-Amylases › Synthesis, biological evaluation, and...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis, biological evaluation, and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis, biological evaluation, and...