Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers.

Humans BRCA1 Protein / deficiency BRCA2 Protein / deficiency Chromosome Inversion DNA Repair / genetics Neoplasms / genetics Translocation, Genetic / genetics Homologous Recombination Cytogenetic Analysis Chromosome Aberrations / classification

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 18 08 2021
accepted: 20 07 2023
medline: 8 9 2023
pubmed: 17 8 2023
entrez: 16 8 2023
Statut: ppublish

Résumé

Homologous recombination (HR) deficiency is associated with DNA rearrangements and cytogenetic aberrations

Identifiants

DOI: 10.1038/s41586-023-06461-2 PMID: 37587346 PMC: PMC10482687
pubmed: 37587346
doi: 10.1038/s41586-023-06461-2
pii: 10.1038/s41586-023-06461-2
pmc: PMC10482687
doi:

Substances chimiques

BRCA1 Protein 0
BRCA1 protein, human 0
BRCA2 Protein 0
BRCA2 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

129-137

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA247749
Pays : United States

Informations de copyright

© 2023. The Author(s).

Références

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Auteurs

Jeremy Setton (J)

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Kevin Hadi (K)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.
Physiology and Biophysics PhD program, Weill Cornell Medicine, New York, NY, USA.

Zi-Ning Choo (ZN)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.
Physiology and Biophysics PhD program, Weill Cornell Medicine, New York, NY, USA.

Katherine S Kuchin (KS)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.
Tri-Institutional PhD Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA.

Huasong Tian (H)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.

Arnaud Da Cruz Paula (A)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Joel Rosiene (J)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.
ORCID: 0000-0002-8610-370X

Pier Selenica (P)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Julie Behr (J)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.
Tri-Institutional PhD Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA.

Xiaotong Yao (X)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.
Tri-Institutional PhD Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-5140-6639

Aditya Deshpande (A)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.
Tri-Institutional PhD Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY, USA.

Michael Sigouros (M)

Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-0328-8359

Jyothi Manohar (J)

Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.

Jones T Nauseef (JT)

New York Genome Center, New York, NY, USA.
Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-2302-4171

Juan-Miguel Mosquera (JM)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-4666-6476

Olivier Elemento (O)

Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-8061-9617

Britta Weigelt (B)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-9927-1270

Nadeem Riaz (N)

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-9873-5862

Jorge S Reis-Filho (JS)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0003-2969-3173

Simon N Powell (SN)

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. powells@mskcc.org.
ORCID: 0000-0002-8183-4765

Marcin Imieliński (M)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. mski@mskilab.org.
New York Genome Center, New York, NY, USA. mski@mskilab.org.
Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA. mski@mskilab.org.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. mski@mskilab.org.
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. mski@mskilab.org.
Department of Pathology and Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA. mski@mskilab.org.
ORCID: 0000-0002-2211-4741

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine BRCA1 › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéine BRCA2 › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Inversion de séquence › Inversion chromosomique › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Tumeurs › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Translocation génétique › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Recombinaison homologue › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse cytogénétique › Long-molecule scars of backup DNA repair in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Aberrations des chromosomes › Long-molecule scars of backup DNA repair in...