Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 09 2023
16 09 2023
Historique:
received:
14
10
2022
accepted:
07
09
2023
medline:
18
9
2023
pubmed:
17
9
2023
entrez:
16
9
2023
Statut:
epublish
Résumé
The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are predicted to bind various RNA-binding proteins, compromise their function and cause cytotoxicity. Here we identify phenylalanine-tRNA synthetase (FARS) subunit alpha (FARSA) as the main interactor of the CCCCGG antisense repeat RNA in cytosol. The aminoacylation of tRNA
Identifiants
pubmed: 37717009
doi: 10.1038/s41467-023-41511-3
pii: 10.1038/s41467-023-41511-3
pmc: PMC10505166
doi:
Substances chimiques
C9orf72 Protein
0
Phenylalanine
47E5O17Y3R
RNA, Transfer, Phe
0
RNA, Antisense
0
C9orf72 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5764Informations de copyright
© 2023. Springer Nature Limited.
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