Photoactivatable Agonist-Antagonist Pair as a Tool for Precise Spatiotemporal Control of Serotonin Receptor 2C Signaling.
5-HT2C
GPCR
calcium signaling
photocaging
serotonin
synapse
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
04 10 2023
04 10 2023
Historique:
medline:
5
10
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
ppublish
Résumé
Orthogonal recreation of the signaling profile of a chemical synapse is a current challenge in neuroscience. This is due in part to the kinetics of synaptic signaling, where neurotransmitters are rapidly released and quickly cleared by active reuptake machinery. One strategy to produce a rapid rise in an orthogonally controlled signal is via photocaged compounds. In this work, photocaged compounds are employed to recreate both the rapid rise and equally rapid fall in activation at a chemical synapse. Specifically, a complementary pair of photocages based on BODIPY were conjugated to a 5-HT
Identifiants
pubmed: 37721710
doi: 10.1021/acschemneuro.3c00290
pmc: PMC10557072
doi:
Substances chimiques
Serotonin
333DO1RDJY
Receptor, Serotonin, 5-HT2C
0
Serotonin Receptor Agonists
0
Serotonin 5-HT2 Receptor Agonists
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3665-3673Subventions
Organisme : NIH HHS
ID : S10 OD026946
Pays : United States
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