RNA Repair: Hiding in Plain Sight.
RNA ligase
end healing
end sealing
enzyme discovery
polynucleotide kinase–phosphatase
tRNA restriction
tRNA splicing
Journal
Annual review of genetics
ISSN: 1545-2948
Titre abrégé: Annu Rev Genet
Pays: United States
ID NLM: 0117605
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
medline:
29
11
2023
pubmed:
19
9
2023
entrez:
18
9
2023
Statut:
ppublish
Résumé
Enzymes that phosphorylate, dephosphorylate, and ligate RNA 5' and 3' ends were discovered more than half a century ago and were eventually shown to repair purposeful site-specific endonucleolytic breaks in the RNA phosphodiester backbone. The pace of discovery and characterization of new candidate RNA repair activities in taxa from all phylogenetic domains greatly exceeds our understanding of the biological pathways in which they act. The key questions anent RNA break repair in vivo are (
Identifiants
pubmed: 37722686
doi: 10.1146/annurev-genet-071719-021856
doi:
Substances chimiques
RNA Ligase (ATP)
EC 6.5.1.3
RNA
63231-63-0
RNA, Transfer
9014-25-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM