Design, synthesis and cell imaging of a new 3-thiolflavone fluorescent probe for biothiols.

Fluorescent Dyes / chemistry Cysteine / analysis Optical Imaging / methods Glutathione / analysis Spectrometry, Fluorescence / methods Homocysteine
3-Thiolflavone Bioimaging Biothiols detection Fluorescent probe

Journal

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533

Informations de publication

Date de publication:
15 Jan 2024
Historique:
received: 04 04 2023
revised: 19 09 2023
accepted: 01 10 2023
medline: 8 11 2023
pubmed: 8 10 2023
entrez: 7 10 2023
Statut: ppublish

Résumé

Abnormal levels of intracellular biothiol species, including glutathione (GSH), homocysteine (Hcy), and cysteine (Cys), are closely relevant to a variety of diseases. In this study, we first report the design and synthesis of a 3-thiolflavone-based probe 3-STF with an S-S linkage both as the fluorescence quenching agent and the recognition site. Upon treatment with biothiols, the S-S linkage was cleaved by nucleophilic attack of RS

Identifiants

DOI: 10.1016/j.saa.2023.123487 PMID: 37804711
pubmed: 37804711
pii: S1386-1425(23)01172-1
doi: 10.1016/j.saa.2023.123487
pii:
doi:

Substances chimiques

Fluorescent Dyes 0
Cysteine K848JZ4886
Glutathione GAN16C9B8O
Homocysteine 0LVT1QZ0BA

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

123487

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Hongbo Wei (H)

College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: weihb@nwafu.edu.cn.

Furong Zhan (F)

College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.

Yaqi Zheng (Y)

College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.

Yuanzhen Xu (Y)

College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China. Electronic address: yzxu@nwafu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Design, synthesis and cell imaging of a new...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Design, synthesis and cell imaging of a new...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Design, synthesis and cell imaging of a new...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Design, synthesis and cell imaging of a new...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrométrie de fluorescence › Design, synthesis and cell imaging of a new...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Homocystéine › Design, synthesis and cell imaging of a new...