Advances in regulating vitamin K
Dynamic metabolic regulation
Metabolic engineering
Static metabolic regulation
Vitamin K2
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
08 Nov 2023
08 Nov 2023
Historique:
received:
28
09
2023
accepted:
02
11
2023
medline:
9
11
2023
pubmed:
8
11
2023
entrez:
8
11
2023
Statut:
epublish
Résumé
Vitamin K
Identifiants
pubmed: 37938463
doi: 10.1007/s11274-023-03828-5
pii: 10.1007/s11274-023-03828-5
doi:
Substances chimiques
Vitamin K 2
11032-49-8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8Subventions
Organisme : the National Nature Science Foundation of China
ID : 32372295
Organisme : Outstanding Youth Research Project in Anhui Province Universities
ID : 2023AH020013
Organisme : Anhui university natural science research key project
ID : 2023AH050938
Organisme : Anhui Provincial Undergraduate Innovation and Entrepreneurship Program
ID : 202310363254
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Aguiar TQ, Silva R, Domingues L (2015) Ashbya gossypii beyond industrial riboflavin production: a historical perspective and emerging biotechnological applications. Biotechnol Adv 33:1774–1786
pubmed: 26456510
doi: 10.1016/j.biotechadv.2015.10.001
Ahmed-Hocine B, Marius B, Georg S, Matthias M (2020) Rational engineering of transcriptional riboswitches leads to enhanced metabolite levels in Bacillus subtilis. Metab Eng 61
Altenbuchner J (2016) Editing of the Bacillus subtilis genome by the Crispr-cas9 system. Appl Environ Microbiol 82(17):5421–5427
pubmed: 27342565
pmcid: 4988203
doi: 10.1128/AEM.01453-16
Anesiadis N, Cluett WR, Mahadevan R (2018) Dynamic metabolic engineering for increasing bioprocess productivity. Metab Eng 10:255–266
doi: 10.1016/j.ymben.2008.06.004
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T (2011) Diversity of the early step of the futalosine pathway. Antimicrob Agents Chemother 55(2):913
pubmed: 21098241
doi: 10.1128/AAC.01362-10
Begley M, Gahan CG, Kollas AK, Hintz M, Hill C, Jomaa H, Eberl M (2004) The interplay between classical and alternative isoprenoid biosynthesis controls γδ T cell bioactivity of Listeria monocytogenes. FEBS Lett 561:99–104
pubmed: 15013758
doi: 10.1016/S0014-5793(04)00131-0
Berenjian A, Mahanama R, Talbot A, Regtop H, Kavanagh J, Dehghani F (2014) Designing of an intensification process for biosynthesis and recovery of menaquinone-7. Appl Biochem Biotechnol 172:1347–1357
pubmed: 24173914
doi: 10.1007/s12010-013-0602-7
Bhalerao S, Clandinin TR (2012) Vitamin K2 takes charge. Science 336:1241–1242
pubmed: 22679087
doi: 10.1126/science.1223812
Binkley SB, Maccorquodale DW, Thayer A, Doisy EA (1939) The isolation of vitamin K
doi: 10.1016/S0021-9258(18)73574-6
Boucher Y, Doolittle WF (2000) The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways. Mol Microbiol 37:703–716
pubmed: 10972794
doi: 10.1046/j.1365-2958.2000.02004.x
Boucher Y, Huber H, L’Haridon S, Stetter KO, Doolittle WF (2001) Bacterial origin for the isoprenoid biosynthesis enzyme HMG-CoA reductase of the archaeal orders Thermoplasmatales and Archaeoglobales. Mol Biol Evol 18:1378–1388
pubmed: 11420376
doi: 10.1093/oxfordjournals.molbev.a003922
Che J, Liu B, Liu G, Chen Q, Huang D (2018) Induced mutation breeding of Brevibacillus Brevis FJAT-0809-GLX for improving ethylparaben production and its application in the biocontrol of Lasiodiplodia theobromae. Postharvest Biol Technol 146:60–67
doi: 10.1016/j.postharvbio.2018.08.011
Chen L, Zeng AP (2017) Rational design and metabolic analysis of Escherichia coli for effective production of l-tryptophan at high concentration. Appl Microbiol Biotechnol 101:559–568
pubmed: 27599980
doi: 10.1007/s00253-016-7772-5
Chen T, Xia H, Cui S, Lv X, Li X, Liu Y, Li J, Du G, Liu L (2020) Combinatorial methylerythritol phosphate pathway engineering and process optimization for increased menaquinone-7 synthesis in Bacillus subtilis. J Microbiol Biotechnol 30:762–769
pubmed: 32482943
pmcid: 9745656
doi: 10.4014/jmb.1912.12008
Choi SR, Larson MA, Hinrichs SH, Bartling AM, Frandsen J, Narayanasamy P (2016) Discovery of bicyclic inhibitors against menaquinone biosynthesis. Future Med Chem 8(1):11–16
pubmed: 26699277
pmcid: 5558544
doi: 10.4155/fmc.15.168
Choi S, Lee HN, Park E, Lee SJ, Kim ES (2020) Recent advances in microbial production of cis, cis-muconic acid. Biomolecules 10:1238
pubmed: 32854378
pmcid: 7564838
doi: 10.3390/biom10091238
Cotrim CA, Weidner A, Strehmel N, Bisol TB, Meyer D, Brandt W, Wessjohann PLA, Stubbs PMT (2017) A distinct aromatic prenyltransferase associated with the futalosine pathway. Chemistryselect 2(29):9319–9325
doi: 10.1002/slct.201702151
Cui S, Lv X, Wu Y, Li J, Du G, Ledesma-Amaro R, Liu L (2019) Engineering a bifunctional Phr60-Rap60-Spo0A quorum-sensing molecular switch for dynamic fine-tuning of menaquinone-7 synthesis in Bacillus subtilis. ACS Synth Biol 8:1826–1837
pubmed: 31257862
doi: 10.1021/acssynbio.9b00140
Cui S, Xia H, Chen T, Gu Y, Lv X, Liu YF, Li JH, Du GC, Liu L (2020) Cell membrane and electron transfer engineering for improved synthesis of menaquinone-7 in Bacillus subtilis. iScience 23(3):100918
pubmed: 32109677
pmcid: 7044751
doi: 10.1016/j.isci.2020.100918
Dairi T (2012) Menaquinone biosyntheses in microorganisms. Meth Enzymol 515:107–122
doi: 10.1016/B978-0-12-394290-6.00006-9
Dam H (1967) Historical survey and introduction. Vitam Horm 24:295–306
doi: 10.1016/S0083-6729(08)60208-3
Dam H (2010) The antihaemorrhagic vitamin of the chick. Nutr Rev 31(4):121–121
doi: 10.1111/j.1753-4887.1973.tb05050.x
Ding XM, Zheng ZM, Zhao GH, Wang L, Wang H, Yang Q, Zhang MX, Li LY, Wang P (2022) Bottom–up synthetic biology approach for improving the efficiency of menaquinone–7 synthesis in Bacillus subtilis. Microb Cell Fact 21:101
pubmed: 35643569
pmcid: 9148487
doi: 10.1186/s12934-022-01823-3
Eisenreich W, Rohdich F, Bacher A (2001) Deoxyxylulose phosphate pathway to terpenoids. Trends Plant Sci 6:78–84
pubmed: 11173292
doi: 10.1016/S1360-1385(00)01812-4
Frank A, Groll M (2017) The methylerythritol phosphate pathway to isoprenoids. Chem Rev 117:5675–5703
pubmed: 27995802
doi: 10.1021/acs.chemrev.6b00537
Gao Q, Chen H, Wang W, Huang J, Tao Y, Lin B (2020) Menaquinone-7 production in engineered Escherichia coli. World J Microbiol Biotechnol 36(9):132
pubmed: 32737601
doi: 10.1007/s11274-020-02880-9
Gao Q, Chen H, Wang G, Yang W, Zhong X, Liu J, Huo X, Liu W, Huang J, Tao Y, Lin B (2021) Highly efficient production of menaquinone-7 from glucose by metabolically engineered Escherichia coli. ACS Synth Biol 10(4):756–765
pubmed: 33755417
doi: 10.1021/acssynbio.0c00568
García-Moyano A, Larsen Ø, Gaykawad S, Christakou E, Boccadoro C, Puntervoll P (2020) Fragment exchange plasmid tools for CRISPR/Cas9-mediated gene integration and protease production in Bacillus subtilis. Appl Environ Microbiol 87(1)
Goodman SR, Marrs BL, Narconis RJ, Olson RE (1976) Isolation and description of a menaquinone mutant from Bacillus licheniformis. J Bacteriol 125:282–289
pubmed: 1245457
pmcid: 233361
doi: 10.1128/jb.125.1.282-289.1976
Guo RT, Kuo CJ, Ko TP, Chou CC, Liang PH, Wang AH (2004) A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products. Biochemistry 43:7678–7686
pubmed: 15196010
doi: 10.1021/bi036336d
Halder M, Petsophonsakul P, Akbulut AC, Pavlic A, Bohan F, Anderson E, Maresz K, Kramann R, Schurgers L (2019) Vitamin K: double bonds beyond coagulation insights into differences between vitamin K
pubmed: 30791399
pmcid: 6413124
doi: 10.3390/ijms20040896
Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP (2015) Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. Proteins 83:37–45
pubmed: 24895191
doi: 10.1002/prot.24618
Hao W, Suo F, Lin Q, Chen Qi, Zhou L, Liu Z (2020) Design and construction of portable CRISPR-cpf1-mediated genome editing in Bacillus subtilis 168 oriented toward multiple utilities. Front Bioeng Biotechnol 8:524676
pubmed: 32984297
pmcid: 7492563
doi: 10.3389/fbioe.2020.524676
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T (2008) An alternative menaquinone biosynthetic pathway operating in microorganisms. Science 321(5896):1670–1673
pubmed: 18801996
doi: 10.1126/science.1160446
Hiratsuka T, Itoh N, Seto H, Dairi T (2009) Enzymatic properties of futalosine hydrolase, an enzyme essential to a newly identified menaquinone biosynthetic pathway. Biosci Biotechnol Biochem 73(5):1137–1141
pubmed: 19420717
doi: 10.1271/bbb.80906
Hong J, Park SH, Kim S, Kim SW, Hahn JS (2019) Efficient production of lycopene in Saccharomyces cerevisiae by enzyme engineering and increasing membrane flexibility and NADPH production. Appl Microbiol Biotechnol 103:211–223
pubmed: 30343427
doi: 10.1007/s00253-018-9449-8
Ikeda M (2006) Towards bacterial strains overproducing l-tryptophan and other aromatics by metabolic engineering. Appl Microbiol Biot 69:615–626
doi: 10.1007/s00253-005-0252-y
Jiang M, Zhang H (2016) Engineering the shikimate pathway for biosynthesis of molecules with pharmaceutical activities in E. Coli. Curr Opin Biotechnol 42:1–6
doi: 10.1016/j.copbio.2016.01.016
Johnston JM, Bulloch EM (2020) Advances in menaquinone biosynthesis: sublocalisation and allosteric regulation. Curr Opin Struct Biol 65:33–41
pubmed: 32634692
doi: 10.1016/j.sbi.2020.05.005
Joshi S, Fedoseyenko D, Mahanta N, Manion H, Naseem S, Dairi T, Begley TP (2018) Novel enzymology in futalosine-dependent menaquinone biosynthesis. Curr Opin Chem Biol 47:134–141
pubmed: 30447488
doi: 10.1016/j.cbpa.2018.09.015
Kawamukai M (2018) Biosynthesis and applications of prenylquinones. Biosci Biotechnol Biochem 82:963–977
pubmed: 29457959
doi: 10.1080/09168451.2018.1433020
Kim RQ, Offen WA, Davies GJ, Stubbs KA (2014) Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway. Acta Crystallogr 70(1):177–185
Kim B, Binkley R, Kim HU, Lee SY (2018) Metabolic engineering of Escherichia coli for the enhanced production of l-tyrosine. Biotechnol Bioeng 115:2554–2564
pubmed: 30019750
doi: 10.1002/bit.26797
Kim H, Kim SY, Sim GY, Ahn JH (2020) Synthesis of 4-hydroxybenzoic acid derivatives in Escherichia coli. J Agric Food Chem 68:9743–9749
pubmed: 32786833
doi: 10.1021/acs.jafc.0c03149
Kong MK, Lee PC (2011) Metabolic engineering of menaquinone-8 pathway of Escherichia coli as a microbial platform for vitamin K production. Biotechnol Bioeng 108:1997–2002
pubmed: 21445887
doi: 10.1002/bit.23142
Koyama T, Tajima M, Sano H, Doi T, Koike-Takeshita A, Obata S (1996) Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. Biochemistry 35:9533–9538
pubmed: 8755734
doi: 10.1021/bi960137v
Kuzuyama T (2017) Biosynthetic studies on terpenoids produced by Streptomyces. J Antibiot (Tokyo) 70:811–818
pubmed: 28196976
doi: 10.1038/ja.2017.12
Kuzuyama T, Seto H (2003) Diversity of the biosynthesis of the isoprene units. Nat Prod Rep 20:171–183
pubmed: 12735695
doi: 10.1039/b109860h
Lal N, Berenjian A (2020) Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Appl Microbiol Biotechnol 104:2765–2776
pubmed: 32009201
doi: 10.1007/s00253-020-10409-1
Lange BM, Rujan T, Martin W, Croteau R (2000) Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc Natl Acad Sci USA 97:13172–13177
pubmed: 11078528
pmcid: 27197
doi: 10.1073/pnas.240454797
Laupitz R, Hecht S, Amslinger S, Zepeck F, Kaiser J, Richter G, Schramek N, Steinbacher S, Huber R, Arigoni D (2004) Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. Eur J Biochem 271:2658–2669
pubmed: 15206931
doi: 10.1111/j.1432-1033.2004.04194.x
Lee JH, Wendisch VF (2017) Biotechnological production of aromatic compounds of the extended shikimate pathway from renewable biomass. J Biotechnol 257:211–221
pubmed: 27871872
doi: 10.1016/j.jbiotec.2016.11.016
Li Y, Wang G (2016) Strategies of isoprenoids production in engineered bacteria. J Appl Microbiol 121:932–940
pubmed: 27428054
doi: 10.1111/jam.13237
Li Q, Fan F, Gao X, Yang C, Bi C, Tang J, Liu T, Zhang X (2017) Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli. Metab Eng 44:13–21
pubmed: 28864262
doi: 10.1016/j.ymben.2017.08.005
Lin Y, Shen X, Yuan Q, Yan Y (2013) Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin. Nat Commun 4:2603
pubmed: 24129598
doi: 10.1038/ncomms3603
Liu Y, Wang L, Zheng ZM, Qiu HW, Wang P, Zhao GH, Gong GH, Song JY, Dai J (2015) Improvement of vitamin K
doi: 10.1088/1009-0630/17/2/11
Liu Y, Ding XM, Xue ZL, Hu LX, Cheng Q, Chen MH, Su Y, Zhu B, Xu P (2017) Site-directed mutagenesis of UbiA to promote menaquinone biosynthesis in Elizabethkingia meningoseptica. Process Biochem 58:186–192
doi: 10.1016/j.procbio.2017.05.002
Liu Y, Yang ZM, Xue ZL, Qian SH, Wang Z, Hu LX, Wang J, Zhu H, Ding XM, Yu F (2018) Influence of site-directed mutagenesis of UbiA, overexpression of dxr, menA and ubiE, and supplementation with precursors on menaquinone production in Elizabethkingia meningoseptica. Process Biochem 68:64–72
doi: 10.1016/j.procbio.2018.01.022
Liu CL, Dong HG, Zhan J, Liu X, Yang Y (2019a) Multi-modular engineering for renewable production of isoprene via mevalonate pathway in Escherichia coli. J Appl Microbiol 126(4):1128–1139
pubmed: 30656788
doi: 10.1111/jam.14204
Liu X, Niu H, Li Q, Gu P (2019b) Metabolic engineering for the production of l-phenylalanine in Escherichia coli. Biotech 9:85
Liu SX, Li S, Shen GM, Sukumar N, Krezel AM, Li WK (2021) Structural basis of antagonizing the VK catalytic cycle for anticoagulation. Science 371:652401
doi: 10.1126/science.abc5667
Lv Y, Qian S, Du G, Chen J, Zhou J, Xu P (2019) Coupling feedback genetic circuits with growth phenotype for dynamic population control and intelligent bioproduction. Metab Eng 54:109–116
pubmed: 30940507
doi: 10.1016/j.ymben.2019.03.009
Lyon GJ, Novick RP (2004) Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides 25:1389–1403
pubmed: 15374643
doi: 10.1016/j.peptides.2003.11.026
Ma XC, Zhu SY, Luo MM, Hu XC, Peng C, Huang H, Ren LJ (2019a) Intracellular response of Bacillus natto in response to different oxygen supply and its influence on menaquinone-7 biosynthesis. Bioprocess Biosyst Eng 42:817–828
pubmed: 30758672
doi: 10.1007/s00449-019-02085-x
Ma YW, McClure DD, Somerville MV, Proschogo NW, Dehghani F, KavanaghJM, Coleman NV (2019b) Metabolic engineering of the MEP pathway in Bacillus subtilis for increased biosynthesis of menaquinone-7. ACS Synth Biol 8(7):1620–1630
pubmed: 31250633
doi: 10.1021/acssynbio.9b00077
Mahdinia E, Demirci A, Berenjian A (2017) Production and application of menaquinone-7 (vitamin K
pubmed: 27832506
doi: 10.1007/s11274-016-2169-2
Marles RJ, Roe AL, Oketch-Rabah HA (2017) US pharmacopeial convention safety evaluation of menaquinone-7, a form of vitamin K. Nutr Rev 75:553–578
pubmed: 28838081
doi: 10.1093/nutrit/nux022
Marrero PF, Poulter CD, Edwards PA (1992) Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity. J Biol Chem 267:21873–21878
pubmed: 1400496
doi: 10.1016/S0021-9258(19)36693-1
Meganathan R (2001) Menaquinone and ubiquinone biosynthesis. Biochemistry 40(29):8641–8641
Meganathan R, Kwon O (2011) Biosynthesis of menaquinone (vitamin K
Mishima E, Ito J, Wu ZJ, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada K, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M (2022) A non-canonical VK cycle is a potent ferroptosis suppressor. Nature 608:778–783
pubmed: 35922516
pmcid: 9402432
doi: 10.1038/s41586-022-05022-3
Morishita T, Tamura N, Makino T, Kudo S (1999) Production of menaquinones by lactic acid bacteria. J Dairy Sci 82:1897–1903
pubmed: 10509247
doi: 10.3168/jds.S0022-0302(99)75424-X
Noda S, Kondo A (2017) Recent advances in microbial production of aromatic chemicals and derivatives. Trends Biotechnol 35:785–796
pubmed: 28645530
doi: 10.1016/j.tibtech.2017.05.006
Partow S, Siewers V, Daviet L, Schalk M, Nielsen J (2012) Reconstruction and evaluation of the synthetic bacterial MEP pathway in Saccharomyces cerevisiae. PLoS ONE 7(12):e52498
pubmed: 23285068
pmcid: 3532213
doi: 10.1371/journal.pone.0052498
Paudel A, Hamamoto H, Panthee S, Sekimizu K (2016) Menaquinone as a potential target of antibacterial agents. Drug Discov Ther 10(3):123–128
pubmed: 27431268
doi: 10.5582/ddt.2016.01041
Puri A, Iqubal M, Zafar R, Panda BP (2015) Influence of physical, chemical and inducer treatments on menaquinone-7 biosynthesis by Bacillus subtilis MTCC 2756. Songklanakarin J Sci Technol 37:283–289
Rekhter D, Ludke D, Ding Y, Feussner K, Zienkiewicz K, Lipka V, Wiermer M, Zhang Y, Feussner I (2019) Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid. Science 365:498–502
pubmed: 31371615
doi: 10.1126/science.aaw1720
Rohmer M (2008) From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway. Lipids 43:1095–1107
pubmed: 19011917
doi: 10.1007/s11745-008-3261-7
Sato T, Yamada Y, Ohtani Y, Mitsui N, Murasawa H, Araki S (2001) Production of menaquinone (vitamin K
pubmed: 16232939
doi: 10.1016/S1389-1723(01)80104-3
Shen YP, Fong LS, Yan ZB, Liu JZ (2019) Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli. Biotechnol Biofuels 12:94
pubmed: 31044007
pmcid: 6477704
doi: 10.1186/s13068-019-1438-3
Shimizu Y, Ogasawara Y, Matsumoto A, Dairi T (2018) Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway. J Antibiot 71:968–970
doi: 10.1038/s41429-018-0087-2
Song J, Liu H, Wang L, Dai J, Zheng Z (2014) Enhanced production of vitamin K
Song Y, He S, Abdallah II, Jopkiewicz A, Setroikromo R, van Merkerk R (2021) Engineering of multiple modules to improve amorphadiene production in Bacillus subtilis using Crispr-Cas9. J Agric Food Chem 69(16):4785–4794
pubmed: 33877851
pmcid: 8154554
doi: 10.1021/acs.jafc.1c00498
Tanaka R, Kunisada T, Kushida N, Yamada K, Ikeda S, Noike M, Ono Y, Itoh N, Takami H, Seto H (2011) Branched fatty acids inhibit the biosynthesis of menaquinone in Helicobacter pylori. J Antibiot 64(1):151–153
doi: 10.1038/ja.2010.133
Tani Y, Asahi S, Yamada H (1986) Menaquinone (vitamin K
pubmed: 3761040
doi: 10.3177/jnsv.32.137
Tetali SD (2019) Terpenes and isoprenoids: a wealth of compounds for global use. Planta 249:1–8
pubmed: 30467631
doi: 10.1007/s00425-018-3056-x
Tonhosolo R, D’Alexandri FL, Genta FA, Wunderlich G, Gozzo FC, Eberlin MN (2005) Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium Falciparum. Biochem J 392:117–126
pubmed: 15984931
pmcid: 1317670
doi: 10.1042/BJ20050441
Tsukamoto Y, Kasai M, Kakuda H (2001) Construction of a Bacillus subtilis (natto) with high productivity of vitamin K
pubmed: 11676013
doi: 10.1271/bbb.65.2007
Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Meensel SV, Schaap O, Strooper BD, Meganathan R, Morais VA, Verstreken P (2012) Vitamin K
pubmed: 22582012
doi: 10.1126/science.1218632
Wang C, Zada B, Wei G, Kim SW (2017) Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli. Bioresour Technol 241:430–438
pubmed: 28599221
doi: 10.1016/j.biortech.2017.05.168
Wang Y, Liu L, Jin Z, Zhang D (2021) Microbial cell factories for green production of vitamins. Front Bioeng Biotechnol 9:661562
pubmed: 34222212
pmcid: 8247775
doi: 10.3389/fbioe.2021.661562
Westbrook AW, Moo-Young M, Chou CP (2016) Development of a Crispr-Cas9 tool kit for comprehensive engineering of Bacillus subtilis. Appl Environ Microbiol 82:4876–4895
pubmed: 27260361
pmcid: 4968543
doi: 10.1128/AEM.01159-16
Wu J, Li W, Zhao SG, Qian SH, Wang Z, Zhou MJ, Hu WS, Wang J, Hu LX, Liu Y, Xue ZL (2021) Site-directed mutagenesis of the quorum sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis. Microb Cell Fact 20(1):1–19
doi: 10.1186/s12934-021-01603-5
Xu P (2018) Production of chemicals using dynamic control of metabolic fluxes. Curr Opin Biotechnol 53:12–19
pubmed: 29145021
doi: 10.1016/j.copbio.2017.10.009
Xu JZ, Zhang W (2017) Menaquinone-7 production from maize meal hydrolysate by Bacillus isolates with diphenylamine and analogue resistance. J Zhejiang Univ Sci B 18:462–473
pubmed: 28585422
pmcid: 5482041
doi: 10.1631/jzus.B1600127
Xu L, Dmitry A, Gaynor EC, Tanner ME (2011) 5’-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni. J Biol Chem 286(22):19392–19398
doi: 10.1074/jbc.M111.229781
Xu JZ, Yan WL, Zhang WG (2017) Enhancing menaquinone-7 production in recombinant Bacillus amyloliquefaciens by metabolic pathway engineering. RSC Adv 7(45):28527–28534
doi: 10.1039/C7RA03388E
Yang SM, Cao YX, Sun LM, Li CF, Lin X, Cai ZG, Zhang GY, Song H (2019) Modular pathway engineering of Bacillus subtilis to promote de novo biosynthesis ofmenaquinone-7. ACS Synth Biol 8(1):70–81
pubmed: 30543412
doi: 10.1021/acssynbio.8b00258
Yang Q, Zheng ZM, Zhao GH, Wang L, Wang H, Ding XM, Jiang CX, Li C, Ma GL, Wang P (2022) Engineering microbial consortia of Elizabethkingia meningoseptica and Escherichia coli strains for the biosynthesis of vitamin K
Yu Y, Aairm R, Liu HR, Lv B, Chang PC, Song H, Wang Y, Li C (2020) Engineering Saccharomyces cerevisiae for high yield production of α-amyrin via synergistic remodeling of α-amyrin synthase and expanding the storage pool. Metab Eng 62:72–83
pubmed: 32841679
doi: 10.1016/j.ymben.2020.08.010
Yuan P, Cui S, Liu Y, Li J, Lv X, Liu L, Du G (2020) Combinatorial engineering for improved menaquinone-4 biosynthesis in Bacillus subtilis. Enzyme Microb Technol 141:109652
pubmed: 33051011
doi: 10.1016/j.enzmictec.2020.109652
Yuan P, Sun G, Cui S, Wu Y, Lv X, Liu Y, Li J, Du G, Liu L (2021) Engineering a ComA quorum-sensing circuit to dynamically control the production of menaquinone-4 in Bacillus subtilis. Enzyme Microb Tech 147:109782
doi: 10.1016/j.enzmictec.2021.109782
Zada B, Wang C, Park JB, Jeong SH, Park JE, Singh HB, Kim SW (2018) Metabolic engineering of Escherichia coli for production of mixed isoprenoid alcohols and their derivatives. Biotechnol Biofuels 11:210
pubmed: 30061932
pmcid: 6058358
doi: 10.1186/s13068-018-1210-0
Zhi XY, Yao JC, Tang SK, Huang Y, Li HW, Li WJ (2014) The futalosine pathway played an important role in menaquinone biosynthesis during early prokaryote evolution. Genome Biol Evol 6:149–160
pubmed: 24398376
pmcid: 3914697
doi: 10.1093/gbe/evu007
Zou D, Maina SW, Zhang F, Yan Z, Xin Z (2020) Mining new plipastatins and increasing the total yield using Crispr/cas9 in genome modified Bacillus Subtilis 1A751. J Agric Food Chem 68(41):11358–11367
pubmed: 32930578
doi: 10.1021/acs.jafc.0c03694